Kelly DE - Search Results

1

Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy.

Hoobler EK, Rai G, Warrilow AG, Perry SC, Smyrniotis CJ, Jadhav A, Simeonov A, Parker JE, Kelly DE, Maloney DJ, Kelly SL, Holman TR. Hoobler EK, et al. Among authors: kelly de, kelly sl. PLoS One. 2013 Jun 24;8(6):e65928. doi: 10.1371/journal.pone.0065928. Print 2013. PLoS One. 2013. PMID: 23826084 Free PMC article.

2

Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa.

Warrilow AG, Price CL, Parker JE, Rolley NJ, Smyrniotis CJ, Hughes DD, Thoss V, Nes WD, Kelly DE, Holman TR, Kelly SL. Warrilow AG, et al. Among authors: kelly de, kelly sl. Sci Rep. 2016 Jun 13;6:27690. doi: 10.1038/srep27690. Sci Rep. 2016. PMID: 27291783 Free PMC article.

3

Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51).

Warrilow AG, Hull CM, Rolley NJ, Parker JE, Nes WD, Smith SN, Kelly DE, Kelly SL. Warrilow AG, et al. Among authors: kelly de, kelly sl. Appl Environ Microbiol. 2014 Oct;80(19):6154-66. doi: 10.1128/AEM.01195-14. Epub 2014 Aug 1. Appl Environ Microbiol. 2014. PMID: 25085484 Free PMC article.

4

Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase.

Price CL, Warrilow AG, Parker JE, Mullins JG, Nes WD, Kelly DE, Kelly SL. Price CL, et al. Among authors: kelly de, kelly sl. Appl Environ Microbiol. 2015 May 15;81(10):3379-86. doi: 10.1128/AEM.03965-14. Epub 2015 Mar 6. Appl Environ Microbiol. 2015. PMID: 25746994 Free PMC article.

5

Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51).

Lamb DC, Warrilow AG, Rolley NJ, Parker JE, Nes WD, Smith SN, Kelly DE, Kelly SL. Lamb DC, et al. Among authors: kelly de, kelly sl. Antimicrob Agents Chemother. 2015 Aug;59(8):4707-13. doi: 10.1128/AAC.00476-15. Epub 2015 May 26. Antimicrob Agents Chemother. 2015. PMID: 26014948 Free PMC article.

6

In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus.

Warrilow AG, Parker JE, Price CL, Nes WD, Kelly SL, Kelly DE. Warrilow AG, et al. Among authors: kelly de, kelly sl. Antimicrob Agents Chemother. 2015 Dec;59(12):7771-8. doi: 10.1128/AAC.01806-15. Epub 2015 Oct 12. Antimicrob Agents Chemother. 2015. PMID: 26459890 Free PMC article.

7

The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.

Warrilow AG, Parker JE, Price CL, Nes WD, Garvey EP, Hoekstra WJ, Schotzinger RJ, Kelly DE, Kelly SL. Warrilow AG, et al. Among authors: kelly de, kelly sl. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4530-8. doi: 10.1128/AAC.00349-16. Print 2016 Aug. Antimicrob Agents Chemother. 2016. PMID: 27161631 Free PMC article.

8

The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51.

Warrilow AGS, Parker JE, Price CL, Garvey EP, Hoekstra WJ, Schotzinger RJ, Wiederhold NP, Nes WD, Kelly DE, Kelly SL. Warrilow AGS, et al. Among authors: kelly de, kelly sl. Antimicrob Agents Chemother. 2017 Jun 27;61(7):e00333-17. doi: 10.1128/AAC.00333-17. Print 2017 Jul. Antimicrob Agents Chemother. 2017. PMID: 28483956 Free PMC article.

9

Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens.

Warrilow AGS, Parker JE, Price CL, Rolley NJ, Nes WD, Kelly DE, Kelly SL. Warrilow AGS, et al. Among authors: kelly de. Int J Antimicrob Agents. 2019 Oct;54(4):449-455. doi: 10.1016/j.ijantimicag.2019.07.011. Epub 2019 Jul 13. Int J Antimicrob Agents. 2019. PMID: 31310805

10

Small-Molecule Inhibitors Targeting Sterol 14α-Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against Candida albicans.

Binjubair FA, Parker JE, Warrilow AG, Puri K, Braidley PJ, Tatar E, Kelly SL, Kelly DE, Simons C. Binjubair FA, et al. Among authors: kelly de. ChemMedChem. 2020 Jul 20;15(14):1294-1309. doi: 10.1002/cmdc.202000250. Epub 2020 Jun 22. ChemMedChem. 2020. PMID: 32459374 Free PMC article.

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