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Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey.
Jensen KK, Tadin-Strapps M, Wang SP, Hubert J, Kan Y, Ma Y, McLaren DG, Previs SF, Herath KB, Mahsut A, Liaw A, Wang S, Stout SJ, Keohan C, Forrest G, Coelho D, Yendluri S, Williams S, Koser M, Bartz S, Akinsanya KO, Pinto S. Jensen KK, et al. Among authors: herath kb. J Lipid Res. 2016 Dec;57(12):2150-2162. doi: 10.1194/jlr.M071498. Epub 2016 Oct 5. J Lipid Res. 2016. PMID: 27707816 Free PMC article.
Glucagon receptor antagonism induces increased cholesterol absorption.
Guan HP, Yang X, Lu K, Wang SP, Castro-Perez JM, Previs S, Wright M, Shah V, Herath K, Xie D, Szeto D, Forrest G, Xiao JC, Palyha O, Sun LP, Andryuk PJ, Engel SS, Xiong Y, Lin S, Kelley DE, Erion MD, Davis HR, Wang L. Guan HP, et al. Among authors: herath k. J Lipid Res. 2015 Nov;56(11):2183-95. doi: 10.1194/jlr.M060897. Epub 2015 Sep 15. J Lipid Res. 2015. PMID: 26373568 Free PMC article.
The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species.
McLaren DG, He T, Wang SP, Mendoza V, Rosa R, Gagen K, Bhat G, Herath K, Miller PL, Stribling S, Taggart A, Imbriglio J, Liu J, Chen D, Pinto S, Balkovec JM, DeVita RJ, Marsh DJ, Castro-Perez JM, Strack A, Johns DG, Previs SF, Hubbard BK, Roddy TP. McLaren DG, et al. Among authors: herath k. J Lipid Res. 2011 Jun;52(6):1150-1161. doi: 10.1194/jlr.M011049. Epub 2011 Mar 17. J Lipid Res. 2011. PMID: 21415123 Free PMC article.
Demonstration of diet-induced decoupling of fatty acid and cholesterol synthesis by combining gene expression array and 2H2O quantification.
Jensen KK, Previs SF, Zhu L, Herath K, Wang SP, Bhat G, Hu G, Miller PL, McLaren DG, Shin MK, Vogt TF, Wang L, Wong KK, Roddy TP, Johns DG, Hubbard BK. Jensen KK, et al. Among authors: herath k. Am J Physiol Endocrinol Metab. 2012 Jan 15;302(2):E209-17. doi: 10.1152/ajpendo.00436.2011. Epub 2011 Nov 1. Am J Physiol Endocrinol Metab. 2012. PMID: 22045313 Free article.
113 results