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DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates.
McLaren DG, Han S, Murphy BA, Wilsie L, Stout SJ, Zhou H, Roddy TP, Gorski JN, Metzger DE, Shin MK, Reilly DF, Zhou HH, Tadin-Strapps M, Bartz SR, Cumiskey AM, Graham TH, Shen DM, Akinsanya KO, Previs SF, Imbriglio JE, Pinto S. McLaren DG, et al. Among authors: murphy ba. Cell Metab. 2018 Jun 5;27(6):1236-1248.e6. doi: 10.1016/j.cmet.2018.04.004. Epub 2018 Apr 26. Cell Metab. 2018. PMID: 29706567 Free article.
Glucagon like receptor 1/ glucagon dual agonist acutely enhanced hepatic lipid clearance and suppressed de novo lipogenesis in mice.
More VR, Lao J, McLaren DG, Cumiskey AM, Murphy BA, Chen Y, Previs S, Stout S, Patel R, Satapati S, Li W, Kowalik E, Szeto D, Nawrocki A, Pocai A, Wang L, Carrington P. More VR, et al. Among authors: murphy ba. PLoS One. 2017 Oct 24;12(10):e0186586. doi: 10.1371/journal.pone.0186586. eCollection 2017. PLoS One. 2017. PMID: 29065174 Free PMC article.
A rapid method for cross-species quantitation of apolipoproteins A1, B48 and B100 in plasma by ultra-performance liquid chromatography/tandem mass spectrometry.
Lassman ME, McLaughlin TM, Somers EP, Stefanni AC, Chen Z, Murphy BA, Bierilo KK, Flattery AM, Wong KK, Castro-Perez JM, Hubbard BK, Roddy TP. Lassman ME, et al. Among authors: murphy ba. Rapid Commun Mass Spectrom. 2012 Jan 30;26(2):101-8. doi: 10.1002/rcm.5296. Rapid Commun Mass Spectrom. 2012. PMID: 22173797
Potential mechanism of enhanced postprandial glucagon-like peptide-1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor.
Liu J, McLaren DG, Chen D, Kan Y, Stout SJ, Shen X, Murphy BA, Forrest G, Karanam B, Sonatore L, He S, Roddy TP, Pinto S. Liu J, et al. Among authors: murphy ba. Pharmacol Res Perspect. 2015 Nov 30;3(6):e00193. doi: 10.1002/prp2.193. eCollection 2015 Dec. Pharmacol Res Perspect. 2015. PMID: 27022467 Free PMC article.
Use of [13C18] oleic acid and mass isotopomer distribution analysis to study synthesis of plasma triglycerides in vivo: analytical and experimental considerations.
McLaren DG, Cardasis HL, Stout SJ, Wang SP, Mendoza V, Castro-Perez JM, Miller PL, Murphy BA, Cumiskey AM, Cleary MA, Johns DG, Previs SF, Roddy TP. McLaren DG, et al. Among authors: murphy ba. Anal Chem. 2013 Jul 2;85(13):6287-94. doi: 10.1021/ac400363k. Epub 2013 Jun 10. Anal Chem. 2013. PMID: 23668715
Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors.
Imbriglio JE, Shen DM, Liang R, Marby K, You M, Youm HW, Feng Z, London C, Xiong Y, Tata J, Verras A, Garcia-Calvo M, Song X, Addona GH, McLaren DG, He T, Murphy B, Metzger DE, Salituro G, Deckman D, Chen Q, Jin X, Stout SJ, Wang SP, Wilsie L, Palyha O, Han S, Hubbard BK, Previs SF, Pinto S, Taggart A. Imbriglio JE, et al. J Med Chem. 2015 Dec 10;58(23):9345-53. doi: 10.1021/acs.jmedchem.5b01345. Epub 2015 Nov 20. J Med Chem. 2015. PMID: 26561979
Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition.
Liu W, Shao PP, Liang GB, Bawiec J, He J, Aster SD, Wu M, Chicchi G, Wang J, Tsao KL, Shang J, Salituro G, Zhou YP, Li C, Akiyama TE, Metzger DE, Murphy BA, Howard AD, Weber AE, Duffy JL. Liu W, et al. Among authors: murphy ba. ACS Med Chem Lett. 2018 Sep 12;9(11):1082-1087. doi: 10.1021/acsmedchemlett.8b00305. eCollection 2018 Nov 8. ACS Med Chem Lett. 2018. PMID: 30429949 Free PMC article.
Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors.
Shen HC, Ding FX, Jiang J, Verras A, Chabin RM, Xu S, Tong X, Chen Q, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, Murphy BA, Gorski JN, Wiltsie J, SinhaRoy R, Hale JJ, Pinto S, Shen DM. Shen HC, et al. Among authors: murphy ba. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1550-6. doi: 10.1016/j.bmcl.2012.01.002. Epub 2012 Jan 10. Bioorg Med Chem Lett. 2012. PMID: 22264488
310 results