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Histone deacetylase inhibitor enhances recovery after AKI.
Cianciolo Cosentino C, Skrypnyk NI, Brilli LL, Chiba T, Novitskaya T, Woods C, West J, Korotchenko VN, McDermott L, Day BW, Davidson AJ, Harris RC, de Caestecker MP, Hukriede NA. Cianciolo Cosentino C, et al. J Am Soc Nephrol. 2013 May;24(6):943-53. doi: 10.1681/ASN.2012111055. Epub 2013 Apr 25. J Am Soc Nephrol. 2013. PMID: 23620402 Free PMC article.
Delayed treatment with PTBA analogs reduces postinjury renal fibrosis after kidney injury.
Skrypnyk NI, Sanker S, Skvarca LB, Novitskaya T, Woods C, Chiba T, Patel K, Goldberg ND, McDermott L, Vinson PN, Calcutt MW, Huryn DM, Vernetti LA, Vogt A, Hukriede NA, de Caestecker MP. Skrypnyk NI, et al. Among authors: mcdermott l. Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F705-F716. doi: 10.1152/ajprenal.00503.2015. Epub 2015 Dec 9. Am J Physiol Renal Physiol. 2016. PMID: 26661656 Free PMC article.
Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.
Pei F, Li H, Henderson MJ, Titus SA, Jadhav A, Simeonov A, Cobanoglu MC, Mousavi SH, Shun T, McDermott L, Iyer P, Fioravanti M, Carlisle D, Friedlander RM, Bahar I, Taylor DL, Lezon TR, Stern AM, Schurdak ME. Pei F, et al. Sci Rep. 2017 Dec 19;7(1):17803. doi: 10.1038/s41598-017-17378-y. Sci Rep. 2017. PMID: 29259176 Free PMC article.
GAC inhibitors with a 4-hydroxypiperidine spacer: Requirements for potency.
McDermott L, Koes D, Mohammed S, Iyer P, Boby M, Balasubramanian V, Geedy M, Katt W, Cerione R. McDermott L, et al. Bioorg Med Chem Lett. 2019 Oct 1;29(19):126632. doi: 10.1016/j.bmcl.2019.126632. Epub 2019 Aug 20. Bioorg Med Chem Lett. 2019. PMID: 31474484 Free PMC article.
Design and evaluation of novel glutaminase inhibitors.
McDermott LA, Iyer P, Vernetti L, Rimer S, Sun J, Boby M, Yang T, Fioravanti M, O'Neill J, Wang L, Drakes D, Katt W, Huang Q, Cerione R. McDermott LA, et al. Bioorg Med Chem. 2016 Apr 15;24(8):1819-39. doi: 10.1016/j.bmc.2016.03.009. Epub 2016 Mar 7. Bioorg Med Chem. 2016. PMID: 26988803 Free PMC article.
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.
Marani M, Paone A, Fiascarelli A, Macone A, Gargano M, Rinaldo S, Giardina G, Pontecorvi V, Koes D, McDermott L, Yang T, Paiardini A, Contestabile R, Cutruzzolà F. Marani M, et al. Oncotarget. 2016 Jan 26;7(4):4570-83. doi: 10.18632/oncotarget.6726. Oncotarget. 2016. PMID: 26717037 Free PMC article.
62 results