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Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics.
Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R. Yerges-Armstrong LM, et al. Among authors: lewis jp. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11. Clin Pharmacol Ther. 2013. PMID: 23839601 Free PMC article. Clinical Trial.
Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response.
Lewis JP, Fisch AS, Ryan K, O'Connell JR, Gibson Q, Mitchell BD, Shen H, Tanner K, Horenstein RB, Pakzy R, Tantry US, Bliden KP, Gurbel PA, Shuldiner AR. Lewis JP, et al. Clin Pharmacol Ther. 2011 Oct;90(4):568-74. doi: 10.1038/clpt.2011.194. Epub 2011 Aug 31. Clin Pharmacol Ther. 2011. PMID: 21881565 Free PMC article. Clinical Trial.
Pharmacogenomics: application to the management of cardiovascular disease.
Johnson JA, Cavallari LH, Beitelshees AL, Lewis JP, Shuldiner AR, Roden DM. Johnson JA, et al. Among authors: lewis jp. Clin Pharmacol Ther. 2011 Oct;90(4):519-31. doi: 10.1038/clpt.2011.179. Epub 2011 Sep 14. Clin Pharmacol Ther. 2011. PMID: 21918509 Free PMC article.
Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability.
Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sànchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R. Ellero-Simatos S, et al. Among authors: lewis jp. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3(7):e125. doi: 10.1038/psp.2014.22. CPT Pharmacometrics Syst Pharmacol. 2014. PMID: 25029353 Free PMC article.
Prospective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin-Dependent Effects on Platelet Aggregation Pathways.
Backman JD, Yerges-Armstrong LM, Horenstein RB, Newcomer S, Shaub S, Morrisey M, Donnelly P, Drolet M, Tanner K, Pavlovich MA, O'Connell JR, Mitchell BD, Lewis JP. Backman JD, et al. Among authors: lewis jp. Clin Transl Sci. 2017 Mar;10(2):102-109. doi: 10.1111/cts.12438. Epub 2017 Jan 11. Clin Transl Sci. 2017. PMID: 28075528 Free PMC article.
Genome sequencing unveils a regulatory landscape of platelet reactivity.
Keramati AR, Chen MH, Rodriguez BAT, Yanek LR, Bhan A, Gaynor BJ, Ryan K, Brody JA, Zhong X, Wei Q; NHLBI Trans-Omics for Precision (TOPMed) Consortium; Kammers K, Kanchan K, Iyer K, Kowalski MH, Pitsillides AN, Cupples LA, Li B, Schlaeger TM, Shuldiner AR, O'Connell JR, Ruczinski I, Mitchell BD, Faraday N, Taub MA, Becker LC, Lewis JP, Mathias RA, Johnson AD. Keramati AR, et al. Among authors: lewis jp. Nat Commun. 2021 Jun 15;12(1):3626. doi: 10.1038/s41467-021-23470-9. Nat Commun. 2021. PMID: 34131117 Free PMC article.
308 results