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Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics.
Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R. Yerges-Armstrong LM, et al. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11. Clin Pharmacol Ther. 2013. PMID: 23839601 Free PMC article. Clinical Trial.
Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability.
Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sànchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R. Ellero-Simatos S, et al. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3(7):e125. doi: 10.1038/psp.2014.22. CPT Pharmacometrics Syst Pharmacol. 2014. PMID: 25029353 Free PMC article.
Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study.
Ellero-Simatos S, Beitelshees AL, Lewis JP, Yerges-Armstrong LM, Georgiades A, Dane A, Harms AC, Strassburg K, Guled F, Hendriks MM, Horenstein RB, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R; Pharmacometabolomics Research Network. Ellero-Simatos S, et al. J Am Heart Assoc. 2015 Oct 26;4(10):e002203. doi: 10.1161/JAHA.115.002203. J Am Heart Assoc. 2015. PMID: 26504148 Free PMC article. Clinical Trial.
Prospective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin-Dependent Effects on Platelet Aggregation Pathways.
Backman JD, Yerges-Armstrong LM, Horenstein RB, Newcomer S, Shaub S, Morrisey M, Donnelly P, Drolet M, Tanner K, Pavlovich MA, O'Connell JR, Mitchell BD, Lewis JP. Backman JD, et al. Clin Transl Sci. 2017 Mar;10(2):102-109. doi: 10.1111/cts.12438. Epub 2017 Jan 11. Clin Transl Sci. 2017. PMID: 28075528 Free PMC article.
Development of a physiology-directed population pharmacokinetic and pharmacodynamic model for characterizing the impact of genetic and demographic factors on clopidogrel response in healthy adults.
Jiang XL, Samant S, Lewis JP, Horenstein RB, Shuldiner AR, Yerges-Armstrong LM, Peletier LA, Lesko LJ, Schmidt S. Jiang XL, et al. Eur J Pharm Sci. 2016 Jan 20;82:64-78. doi: 10.1016/j.ejps.2015.10.024. Epub 2015 Oct 30. Eur J Pharm Sci. 2016. PMID: 26524713 Free PMC article. Clinical Trial.
102 results