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Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced MDA adducts: implications for development of an atheroprotective vaccine.
Gonen A, Hansen LF, Turner WW, Montano EN, Que X, Rafia A, Chou MY, Wiesner P, Tsiantoulas D, Corr M, VanNieuwenhze MS, Tsimikas S, Binder CJ, Witztum JL, Hartvigsen K. Gonen A, et al. Among authors: que x. J Lipid Res. 2014 Oct;55(10):2137-55. doi: 10.1194/jlr.M053256. Epub 2014 Aug 20. J Lipid Res. 2014. PMID: 25143462 Free PMC article.
Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity.
Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. Miller YI, et al. Among authors: que x. Circ Res. 2011 Jan 21;108(2):235-48. doi: 10.1161/CIRCRESAHA.110.223875. Circ Res. 2011. PMID: 21252151 Free PMC article. Review.
PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis.
Senders ML, Que X, Cho YS, Yeang C, Groenen H, Fay F, Calcagno C, Meerwaldt AE, Green S, Miu P, Lobatto ME, Reiner T, Fayad ZA, Witztum JL, Mulder WJM, Pérez-Medina C, Tsimikas S. Senders ML, et al. Among authors: que x. J Am Coll Cardiol. 2018 Jan 23;71(3):321-335. doi: 10.1016/j.jacc.2017.11.036. J Am Coll Cardiol. 2018. PMID: 29348025 Free PMC article.
Oxidation-specific epitopes restrain bone formation.
Ambrogini E, Que X, Wang S, Yamaguchi F, Weinstein RS, Tsimikas S, Manolagas SC, Witztum JL, Jilka RL. Ambrogini E, et al. Among authors: que x. Nat Commun. 2018 Jun 6;9(1):2193. doi: 10.1038/s41467-018-04047-5. Nat Commun. 2018. PMID: 29875355 Free PMC article.
Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.
Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. Que X, et al. Nature. 2018 Jun;558(7709):301-306. doi: 10.1038/s41586-018-0198-8. Epub 2018 Jun 6. Nature. 2018. PMID: 29875409 Free PMC article.
ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis.
Baldan A, Gonen A, Choung C, Que X, Marquart TJ, Hernandez I, Bjorkhem I, Ford DA, Witztum JL, Tarling EJ. Baldan A, et al. Among authors: que x. J Immunol. 2014 Dec 1;193(11):5637-48. doi: 10.4049/jimmunol.1400606. Epub 2014 Oct 22. J Immunol. 2014. PMID: 25339664 Free PMC article.
144 results