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A mouse model of inherited choline kinase β-deficiency presents with specific cardiac abnormalities and a predisposition to arrhythmia.
Tavasoli M, Feridooni T, Feridooni H, Sokolenko S, Mishra A, Lefsay A, Srinivassane S, Reid SA, Rowsell J, Praest M, MacKinnon A, Mammoliti M, Maloney AA, Moraca M, Uaesoontrachoon K, Nagaraju K, Hoffman EP, Pasumarthi KBS, McMaster CR. Tavasoli M, et al. J Biol Chem. 2022 Mar;298(3):101716. doi: 10.1016/j.jbc.2022.101716. Epub 2022 Feb 11. J Biol Chem. 2022. PMID: 35151687 Free PMC article.
Mechanism of action and therapeutic route for a muscular dystrophy caused by a genetic defect in lipid metabolism.
Tavasoli M, Lahire S, Sokolenko S, Novorolsky R, Reid SA, Lefsay A, Otley MOC, Uaesoontrachoon K, Rowsell J, Srinivassane S, Praest M, MacKinnon A, Mammoliti MS, Maloney AA, Moraca M, Pedro Fernandez-Murray J, McKenna M, Sinal CJ, Nagaraju K, Robertson GS, Hoffman EP, McMaster CR. Tavasoli M, et al. Nat Commun. 2022 Mar 23;13(1):1559. doi: 10.1038/s41467-022-29270-z. Nat Commun. 2022. PMID: 35322809 Free PMC article.