Maloney DJ - Search Results

1

Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion.

Srinivasan P, Yasgar A, Luci DK, Beatty WL, Hu X, Andersen J, Narum DL, Moch JK, Sun H, Haynes JD, Maloney DJ, Jadhav A, Simeonov A, Miller LH. Srinivasan P, et al. Among authors: maloney dj. Nat Commun. 2013;4:2261. doi: 10.1038/ncomms3261. Nat Commun. 2013. PMID: 23907321 Free PMC article.

2

Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection.

Dorjsuren D, Kim D, Vyjayanti VN, Maloney DJ, Jadhav A, Wilson DM 3rd, Simeonov A. Dorjsuren D, et al. Among authors: maloney dj. PLoS One. 2012;7(10):e47974. doi: 10.1371/journal.pone.0047974. Epub 2012 Oct 23. PLoS One. 2012. PMID: 23110144 Free PMC article.

3

Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition.

Gormally MV, Dexheimer TS, Marsico G, Sanders DA, Lowe C, Matak-Vinković D, Michael S, Jadhav A, Rai G, Maloney DJ, Simeonov A, Balasubramanian S. Gormally MV, et al. Among authors: maloney dj. Nat Commun. 2014 Nov 12;5:5165. doi: 10.1038/ncomms6165. Nat Commun. 2014. PMID: 25387393 Free PMC article.

4

High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding.

Yasgar A, Furdas SD, Maloney DJ, Jadhav A, Jung M, Simeonov A. Yasgar A, et al. Among authors: maloney dj. PLoS One. 2012;7(9):e45594. doi: 10.1371/journal.pone.0045594. Epub 2012 Sep 20. PLoS One. 2012. PMID: 23029124 Free PMC article.

5

A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.

Liang Q, Dexheimer TS, Zhang P, Rosenthal AS, Villamil MA, You C, Zhang Q, Chen J, Ott CA, Sun H, Luci DK, Yuan B, Simeonov A, Jadhav A, Xiao H, Wang Y, Maloney DJ, Zhuang Z. Liang Q, et al. Among authors: maloney dj. Nat Chem Biol. 2014 Apr;10(4):298-304. doi: 10.1038/nchembio.1455. Epub 2014 Feb 16. Nat Chem Biol. 2014. PMID: 24531842 Free PMC article.

6

Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening.

Hu X, Legler PM, Southall N, Maloney DJ, Simeonov A, Jadhav A. Hu X, et al. Among authors: maloney dj. J Comput Aided Mol Des. 2014 Jul;28(7):765-78. doi: 10.1007/s10822-014-9758-7. Epub 2014 Jun 24. J Comput Aided Mol Des. 2014. PMID: 24958623 Free PMC article.

7

Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties.

Poletto M, Malfatti MC, Dorjsuren D, Scognamiglio PL, Marasco D, Vascotto C, Jadhav A, Maloney DJ, Wilson DM 3rd, Simeonov A, Tell G. Poletto M, et al. Among authors: maloney dj. Mol Carcinog. 2016 May;55(5):688-704. doi: 10.1002/mc.22313. Epub 2015 Apr 11. Mol Carcinog. 2016. PMID: 25865359 Free PMC article.

8

Inhibition of DNA glycosylases via small molecule purine analogs.

Jacobs AC, Calkins MJ, Jadhav A, Dorjsuren D, Maloney D, Simeonov A, Jaruga P, Dizdaroglu M, McCullough AK, Lloyd RS. Jacobs AC, et al. PLoS One. 2013 Dec 9;8(12):e81667. doi: 10.1371/journal.pone.0081667. eCollection 2013. PLoS One. 2013. PMID: 24349107 Free PMC article.

9

Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.

Rai G, Kenyon V, Jadhav A, Schultz L, Armstrong M, Jameson JB, Hoobler E, Leister W, Simeonov A, Holman TR, Maloney DJ. Rai G, et al. Among authors: maloney dj. J Med Chem. 2010 Oct 28;53(20):7392-404. doi: 10.1021/jm1008852. J Med Chem. 2010. PMID: 20866075 Free PMC article.

10

Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.

Rai G, Vyjayanti VN, Dorjsuren D, Simeonov A, Jadhav A, Wilson DM 3rd, Maloney DJ. Rai G, et al. Among authors: maloney dj. J Med Chem. 2012 Apr 12;55(7):3101-12. doi: 10.1021/jm201537d. Epub 2012 Mar 28. J Med Chem. 2012. PMID: 22455312 Free PMC article.

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