Osorio FG - Search Results

1

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.

de la Rosa J, Freije JM, Cabanillas R, Osorio FG, Fraga MF, Fernández-García MS, Rad R, Fanjul V, Ugalde AP, Liang Q, Prosser HM, Bradley A, Cadiñanos J, López-Otín C. de la Rosa J, et al. Among authors: osorio fg. Nat Commun. 2013;4:2268. doi: 10.1038/ncomms3268. Nat Commun. 2013. PMID: 23917225 Free PMC article.

2

Accelerated ageing: from mechanism to therapy through animal models.

Osorio FG, Obaya AJ, López-Otín C, Freije JM. Osorio FG, et al. Transgenic Res. 2009 Feb;18(1):7-15. doi: 10.1007/s11248-008-9226-z. Epub 2008 Nov 18. Transgenic Res. 2009. PMID: 19015945 Review.

3

Cell autonomous and systemic factors in progeria development.

Osorio FG, Ugalde AP, Mariño G, Puente XS, Freije JM, López-Otín C. Osorio FG, et al. Biochem Soc Trans. 2011 Dec;39(6):1710-4. doi: 10.1042/BST20110677. Biochem Soc Trans. 2011. PMID: 22103512 Review.

4

Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome.

Santiago-Fernández O, Osorio FG, Quesada V, Rodríguez F, Basso S, Maeso D, Rolas L, Barkaway A, Nourshargh S, Folgueras AR, Freije JMP, López-Otín C. Santiago-Fernández O, et al. Among authors: osorio fg. Nat Med. 2019 Mar;25(3):423-426. doi: 10.1038/s41591-018-0338-6. Epub 2019 Feb 18. Nat Med. 2019. PMID: 30778239 Free PMC article.

5

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

Varela I, Pereira S, Ugalde AP, Navarro CL, Suárez MF, Cau P, Cadiñanos J, Osorio FG, Foray N, Cobo J, de Carlos F, Lévy N, Freije JM, López-Otín C. Varela I, et al. Among authors: osorio fg. Nat Med. 2008 Jul;14(7):767-72. doi: 10.1038/nm1786. Epub 2008 Jun 29. Nat Med. 2008. PMID: 18587406

6

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function.

Mariño G, Ugalde AP, Fernández AF, Osorio FG, Fueyo A, Freije JM, López-Otín C. Mariño G, et al. Among authors: osorio fg. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16268-73. doi: 10.1073/pnas.1002696107. Epub 2010 Aug 30. Proc Natl Acad Sci U S A. 2010. PMID: 20805469 Free PMC article.

7

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease.

Osorio FG, Varela I, Lara E, Puente XS, Espada J, Santoro R, Freije JM, Fraga MF, López-Otín C. Osorio FG, et al. Aging Cell. 2010 Dec;9(6):947-57. doi: 10.1111/j.1474-9726.2010.00621.x. Epub 2010 Oct 21. Aging Cell. 2010. PMID: 20961378 Free article.

8

Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome.

Puente XS, Quesada V, Osorio FG, Cabanillas R, Cadiñanos J, Fraile JM, Ordóñez GR, Puente DA, Gutiérrez-Fernández A, Fanjul-Fernández M, Lévy N, Freije JM, López-Otín C. Puente XS, et al. Among authors: osorio fg. Am J Hum Genet. 2011 May 13;88(5):650-6. doi: 10.1016/j.ajhg.2011.04.010. Epub 2011 May 5. Am J Hum Genet. 2011. PMID: 21549337 Free PMC article.

9

Splicing-directed therapy in a new mouse model of human accelerated aging.

Osorio FG, Navarro CL, Cadiñanos J, López-Mejía IC, Quirós PM, Bartoli C, Rivera J, Tazi J, Guzmán G, Varela I, Depetris D, de Carlos F, Cobo J, Andrés V, De Sandre-Giovannoli A, Freije JM, Lévy N, López-Otín C. Osorio FG, et al. Sci Transl Med. 2011 Oct 26;3(106):106ra107. doi: 10.1126/scitranslmed.3002847. Sci Transl Med. 2011. PMID: 22030750

10

Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response.

Osorio FG, Bárcena C, Soria-Valles C, Ramsay AJ, de Carlos F, Cobo J, Fueyo A, Freije JM, López-Otín C. Osorio FG, et al. Genes Dev. 2012 Oct 15;26(20):2311-24. doi: 10.1101/gad.197954.112. Epub 2012 Sep 26. Genes Dev. 2012. PMID: 23019125 Free PMC article.

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