Mendillo ML - Search Results

1

A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells.

Petrocca F, Altschuler G, Tan SM, Mendillo ML, Yan H, Jerry DJ, Kung AL, Hide W, Ince TA, Lieberman J. Petrocca F, et al. Among authors: mendillo ml. Cancer Cell. 2013 Aug 12;24(2):182-96. doi: 10.1016/j.ccr.2013.07.008. Cancer Cell. 2013. PMID: 23948298 Free PMC article.

2

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer.

Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, Schnitt SJ, Whitesell L, Tamimi RM, Lindquist S, Ince TA. Santagata S, et al. Among authors: mendillo ml. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18378-83. doi: 10.1073/pnas.1115031108. Epub 2011 Oct 31. Proc Natl Acad Sci U S A. 2011. PMID: 22042860 Free PMC article.

3

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.

Mendillo ML, Santagata S, Koeva M, Bell GW, Hu R, Tamimi RM, Fraenkel E, Ince TA, Whitesell L, Lindquist S. Mendillo ML, et al. Cell. 2012 Aug 3;150(3):549-62. doi: 10.1016/j.cell.2012.06.031. Cell. 2012. PMID: 22863008 Free PMC article.

4

Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer.

Kunder R, Velyunskiy M, Dunne SF, Cho BK, Kanojia D, Begg L, Orriols AM, Fleming-Trujillo E, Vadlamani P, Vialichka A, Bolin R, Perrino JN, Roth D, Clutter MR, Zielinski-Mozny NA, Goo YA, Cristofanilli M, Mendillo ML, Vassilopoulos A, Horiuchi D. Kunder R, et al. Among authors: mendillo ml. Cell Chem Biol. 2022 Mar 17;29(3):358-372.e5. doi: 10.1016/j.chembiol.2021.08.011. Epub 2021 Sep 14. Cell Chem Biol. 2022. PMID: 34525344 Free PMC article.

5

The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.

Scherz-Shouval R, Santagata S, Mendillo ML, Sholl LM, Ben-Aharon I, Beck AH, Dias-Santagata D, Koeva M, Stemmer SM, Whitesell L, Lindquist S. Scherz-Shouval R, et al. Among authors: mendillo ml. Cell. 2014 Jul 31;158(3):564-78. doi: 10.1016/j.cell.2014.05.045. Cell. 2014. PMID: 25083868 Free PMC article.

6

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.

Tsvetkov P, Mendillo ML, Zhao J, Carette JE, Merrill PH, Cikes D, Varadarajan M, van Diemen FR, Penninger JM, Goldberg AL, Brummelkamp TR, Santagata S, Lindquist S. Tsvetkov P, et al. Among authors: mendillo ml. Elife. 2015 Sep 1;4:e08467. doi: 10.7554/eLife.08467. Elife. 2015. PMID: 26327695 Free PMC article.

7

Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia.

Zhou Y, Han C, Wang E, Lorch AH, Serafin V, Cho BK, Gutierrez Diaz BT, Calvo J, Fang C, Khodadadi-Jamayran A, Tabaglio T, Marier C, Kuchmiy A, Sun L, Yacu G, Filip SK, Jin Q, Takahashi YH, Amici DR, Rendleman EJ, Rawat R, Bresolin S, Paganin M, Zhang C, Li H, Kandela I, Politanska Y, Abdala-Valencia H, Mendillo ML, Zhu P, Palhais B, Van Vlierberghe P, Taghon T, Aifantis I, Goo YA, Guccione E, Heguy A, Tsirigos A, Wee KB, Mishra RK, Pflumio F, Accordi B, Basso G, Ntziachristos P. Zhou Y, et al. Among authors: mendillo ml. Cancer Discov. 2020 Sep;10(9):1388-1409. doi: 10.1158/2159-8290.CD-19-1436. Epub 2020 May 22. Cancer Discov. 2020. PMID: 32444465 Free PMC article.

8

Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.

Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA Jr, Whitesell L, Lindquist S. Santagata S, et al. Among authors: mendillo ml. Science. 2013 Jul 19;341(6143):1238303. doi: 10.1126/science.1238303. Science. 2013. PMID: 23869022 Free PMC article.

9

The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis.

Ali ES, Lipońska A, O'Hara BP, Amici DR, Torno MD, Gao P, Asara JM, Yap MF, Mendillo ML, Ben-Sahra I. Ali ES, et al. Among authors: mendillo ml. Mol Cell. 2022 Sep 1;82(17):3284-3298.e7. doi: 10.1016/j.molcel.2022.06.008. Epub 2022 Jun 29. Mol Cell. 2022. PMID: 35772404 Free PMC article.

10

HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models.

Whitesell L, Santagata S, Mendillo ML, Lin NU, Proia DA, Lindquist S. Whitesell L, et al. Among authors: mendillo ml. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18297-302. doi: 10.1073/pnas.1421323111. Epub 2014 Dec 8. Proc Natl Acad Sci U S A. 2014. PMID: 25489079 Free PMC article.

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