Allosteric regulation of tryptophan synthase channeling: the internal aldimine probed by trans-3-indole-3'-acrylate binding.
Casino P, Niks D, Ngo H, Pan P, Brzovic P, Blumenstein L, Barends TR, Schlichting I, Dunn MF.
Casino P, et al. Among authors: niks d.
Biochemistry. 2007 Jul 3;46(26):7728-39. doi: 10.1021/bi700386b. Epub 2007 Jun 9.
Biochemistry. 2007.
PMID: 17559231
Here we employ the chromophoric l-Trp analogue, trans-3-indole-3'-acrylate (IA), and noncleavable alpha-site ligands (ASLs) to probe the allosteric properties of the internal aldimine, E(Ain). The ASLs studied are alpha-d,l-glycerol phosphate (GP) and d-glyceraldehy …
Here we employ the chromophoric l-Trp analogue, trans-3-indole-3'-acrylate (IA), and noncleavable alpha-site ligands (ASLs) to probe the all …