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Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice.
J Pharmacol Exp Ther. 2013 Nov;347(2):325-38. doi: 10.1124/jpet.113.205799. Epub 2013 Aug 21.
J Pharmacol Exp Ther. 2013.
PMID: 23965382
Free PMC article.
Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice.
Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB.
Silber BM, et al.
Pharm Res. 2013 Apr;30(4):932-50. doi: 10.1007/s11095-012-0912-4. Epub 2013 Feb 16.
Pharm Res. 2013.
PMID: 23417511
Free PMC article.
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2-Aminothiazoles with improved pharmacotherapeutic properties for treatment of prion disease.
Li Z, Silber BM, Rao S, Gever JR, Bryant C, Gallardo-Godoy A, Dolghih E, Widjaja K, Elepano M, Jacobson MP, Prusiner SB, Renslo AR.
Li Z, et al.
ChemMedChem. 2013 May;8(5):847-57. doi: 10.1002/cmdc.201300007. Epub 2013 Mar 18.
ChemMedChem. 2013.
PMID: 23509039
Free PMC article.
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Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells.
Silber BM, Gever JR, Rao S, Li Z, Renslo AR, Widjaja K, Wong C, Giles K, Freyman Y, Elepano M, Irwin JJ, Jacobson MP, Prusiner SB.
Silber BM, et al.
Bioorg Med Chem. 2014 Mar 15;22(6):1960-72. doi: 10.1016/j.bmc.2014.01.001. Epub 2014 Jan 9.
Bioorg Med Chem. 2014.
PMID: 24530226
Free PMC article.
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Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.
Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB.
Giles K, et al.
J Pharmacol Exp Ther. 2015 Oct;355(1):2-12. doi: 10.1124/jpet.115.224659. Epub 2015 Jul 29.
J Pharmacol Exp Ther. 2015.
PMID: 26224882
Free PMC article.
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Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice.
Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner SB.
Giles K, et al.
J Pharmacol Exp Ther. 2016 Sep;358(3):537-47. doi: 10.1124/jpet.116.235556. Epub 2016 Jun 17.
J Pharmacol Exp Ther. 2016.
PMID: 27317802
Free PMC article.
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Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity.
Grandjean JM, Jiu AY, West JW, Aoyagi A, Droege DG, Elepano M, Hirasawa M, Hirouchi M, Murakami R, Lee J, Sasaki K, Hirano S, Ohyama T, Tang BC, Vaz RJ, Inoue M, Olson SH, Prusiner SB, Conrad J, Paras NA.
Grandjean JM, et al.
ACS Med Chem Lett. 2020 Jan 30;11(2):127-132. doi: 10.1021/acsmedchemlett.9b00480. eCollection 2020 Feb 13.
ACS Med Chem Lett. 2020.
PMID: 32071678
Free PMC article.
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