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A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.
Nguyen GH, Dexheimer TS, Rosenthal AS, Chu WK, Singh DK, Mosedale G, Bachrati CZ, Schultz L, Sakurai M, Savitsky P, Abu M, McHugh PJ, Bohr VA, Harris CC, Jadhav A, Gileadi O, Maloney DJ, Simeonov A, Hickson ID. Nguyen GH, et al. Among authors: gileadi o. Chem Biol. 2013 Jan 24;20(1):55-62. doi: 10.1016/j.chembiol.2012.10.016. Chem Biol. 2013. PMID: 23352139 Free PMC article.
RecQ helicases in DNA repair and cancer targets.
Newman JA, Gileadi O. Newman JA, et al. Among authors: gileadi o. Essays Biochem. 2020 Oct 26;64(5):819-830. doi: 10.1042/EBC20200012. Essays Biochem. 2020. PMID: 33095241 Free PMC article. Review.
Structure of the human RECQ1 helicase reveals a putative strand-separation pin.
Pike AC, Shrestha B, Popuri V, Burgess-Brown N, Muzzolini L, Costantini S, Vindigni A, Gileadi O. Pike AC, et al. Among authors: gileadi o. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1039-44. doi: 10.1073/pnas.0806908106. Epub 2009 Jan 16. Proc Natl Acad Sci U S A. 2009. PMID: 19151156 Free PMC article.
Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.
Serafim RAM, de Souza Gama FH, Dutra LA, Dos Reis CV, Vasconcelos SNS, da Silva Santiago A, Takarada JE, Di Pillo F, Azevedo H, Mascarello A, Elkins JM, Massirer KB, Gileadi O, Guimarães CRW, Couñago RM. Serafim RAM, et al. Among authors: gileadi o. ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271. doi: 10.1021/acsmedchemlett.9b00082. eCollection 2019 Sep 12. ACS Med Chem Lett. 2019. PMID: 31531195 Free PMC article.
114 results