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A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis.
Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, Deane A, Keely S, Horvat JC, Yang M, Oliver BG, van Rooijen N, Inman MD, Adachi R, Soberman RJ, Hamadi S, Wark PA, Foster PS, Hansbro PM. Beckett EL, et al. Among authors: keely s. J Allergy Clin Immunol. 2013 Mar;131(3):752-62. doi: 10.1016/j.jaci.2012.11.053. Epub 2013 Feb 4. J Allergy Clin Immunol. 2013. PMID: 23380220 Free PMC article.
MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2.
Kim RY, Horvat JC, Pinkerton JW, Starkey MR, Essilfie AT, Mayall JR, Nair PM, Hansbro NG, Jones B, Haw TJ, Sunkara KP, Nguyen TH, Jarnicki AG, Keely S, Mattes J, Adcock IM, Foster PS, Hansbro PM. Kim RY, et al. Among authors: keely s. J Allergy Clin Immunol. 2017 Feb;139(2):519-532. doi: 10.1016/j.jaci.2016.04.038. Epub 2016 Jun 10. J Allergy Clin Immunol. 2017. PMID: 27448447 Free article.
Regulation of IL-12p40 by HIF controls Th1/Th17 responses to prevent mucosal inflammation.
Marks E, Naudin C, Nolan G, Goggins BJ, Burns G, Mateer SW, Latimore JK, Minahan K, Plank M, Foster PS, Callister R, Veysey M, Walker MM, Talley NJ, Radford-Smith G, Keely S. Marks E, et al. Among authors: keely s. Mucosal Immunol. 2017 Sep;10(5):1224-1236. doi: 10.1038/mi.2016.135. Epub 2017 Jan 25. Mucosal Immunol. 2017. PMID: 28120851 Free article.
Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction.
Fricker M, Goggins BJ, Mateer S, Jones B, Kim RY, Gellatly SL, Jarnicki AG, Powell N, Oliver BG, Radford-Smith G, Talley NJ, Walker MM, Keely S, Hansbro PM. Fricker M, et al. Among authors: keely s. JCI Insight. 2018 Feb 8;3(3):e94040. doi: 10.1172/jci.insight.94040. eCollection 2018 Feb 8. JCI Insight. 2018. PMID: 29415878 Free PMC article.
264 results