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LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction.
Sanders LH, Laganière J, Cooper O, Mak SK, Vu BJ, Huang YA, Paschon DE, Vangipuram M, Sundararajan R, Urnov FD, Langston JW, Gregory PD, Zhang HS, Greenamyre JT, Isacson O, Schüle B. Sanders LH, et al. Among authors: isacson o. Neurobiol Dis. 2014 Feb;62:381-6. doi: 10.1016/j.nbd.2013.10.013. Epub 2013 Oct 19. Neurobiol Dis. 2014. PMID: 24148854 Free PMC article.
Recent advances in cell-based therapy for Parkinson disease.
Astradsson A, Cooper O, Vinuela A, Isacson O. Astradsson A, et al. Among authors: isacson o. Neurosurg Focus. 2008;24(3-4):E6. doi: 10.3171/FOC/2008/24/3-4/E5. Neurosurg Focus. 2008. PMID: 18341409 Review.
Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum.
de Chevigny A, Cooper O, Vinuela A, Reske-Nielsen C, Lagace DC, Eisch AJ, Isacson O. de Chevigny A, et al. Among authors: isacson o. Stem Cells. 2008 Sep;26(9):2349-60. doi: 10.1634/stemcells.2008-0080. Epub 2008 Jun 12. Stem Cells. 2008. PMID: 18556510 Free PMC article.
No evidence for disease-like processes in fetal transplants.
Hallett PJ, Cooper O, Isacson O. Hallett PJ, et al. Among authors: isacson o. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):E104; author reply E105. doi: 10.1073/pnas.0908169106. Epub 2009 Sep 2. Proc Natl Acad Sci U S A. 2009. PMID: 19805203 Free PMC article. No abstract available.
298 results