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BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models.
Mol Cancer Ther. 2013 Nov;12(11):2319-30. doi: 10.1158/1535-7163.MCT-12-0993-T. Epub 2013 Oct 29.
Mol Cancer Ther. 2013.
PMID: 24170767
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.
Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, Cao Y, Shujath J, Gawlak S, Eveleigh D, Rowley B, Liu L, Adnane L, Lynch M, Auclair D, Taylor I, Gedrich R, Voznesensky A, Riedl B, Post LE, Bollag G, Trail PA.
Wilhelm SM, et al.
Cancer Res. 2004 Oct 1;64(19):7099-109. doi: 10.1158/0008-5472.CAN-04-1443.
Cancer Res. 2004.
PMID: 15466206
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Constitutively active receptor tyrosine kinases as oncogenes in preclinical models for cancer therapeutics.
Kellar KA, Lorenzi MV, Ho CP, You D, Wen ML, Ryseck RP, Oppenheimer S, Fink BE, Vite GD, Rowley BR, Yu C, Bol DK, Lee FY, Wong TW.
Kellar KA, et al. Among authors: rowley br.
Mol Cancer Ther. 2006 Jun;5(6):1571-6. doi: 10.1158/1535-7163.MCT-06-0078.
Mol Cancer Ther. 2006.
PMID: 16818516
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Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor.
Carboni JM, Lee AV, Hadsell DL, Rowley BR, Lee FY, Bol DK, Camuso AE, Gottardis M, Greer AF, Ho CP, Hurlburt W, Li A, Saulnier M, Velaparthi U, Wang C, Wen ML, Westhouse RA, Wittman M, Zimmermann K, Rupnow BA, Wong TW.
Carboni JM, et al. Among authors: rowley br.
Cancer Res. 2005 May 1;65(9):3781-7. doi: 10.1158/0008-5472.CAN-04-4602.
Cancer Res. 2005.
PMID: 15867374
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Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase.
Mallick-Wood CA, Pao W, Cheng AM, Lewis JM, Kulkarni S, Bolen JB, Rowley B, Tigelaar RE, Pawson T, Hayday AC.
Mallick-Wood CA, et al.
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9704-9. doi: 10.1073/pnas.93.18.9704.
Proc Natl Acad Sci U S A. 1996.
PMID: 8790395
Free PMC article.
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Syk tyrosine kinase required for mouse viability and B-cell development.
Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T.
Cheng AM, et al.
Nature. 1995 Nov 16;378(6554):303-6. doi: 10.1038/378303a0.
Nature. 1995.
PMID: 7477353
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