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Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.
Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Henderson NC, et al. Among authors: griggs dw. Nat Med. 2013 Dec;19(12):1617-24. doi: 10.1038/nm.3282. Epub 2013 Nov 10. Nat Med. 2013. PMID: 24216753 Free PMC article.
αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis.
Murray IR, Gonzalez ZN, Baily J, Dobie R, Wallace RJ, Mackinnon AC, Smith JR, Greenhalgh SN, Thompson AI, Conroy KP, Griggs DW, Ruminski PG, Gray GA, Singh M, Campbell MA, Kendall TJ, Dai J, Li Y, Iredale JP, Simpson H, Huard J, Péault B, Henderson NC. Murray IR, et al. Among authors: griggs dw. Nat Commun. 2017 Oct 24;8(1):1118. doi: 10.1038/s41467-017-01097-z. Nat Commun. 2017. PMID: 29061963 Free PMC article.
A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.
Minutti CM, Modak RV, Macdonald F, Li F, Smyth DJ, Dorward DA, Blair N, Husovsky C, Muir A, Giampazolias E, Dobie R, Maizels RM, Kendall TJ, Griggs DW, Kopf M, Henderson NC, Zaiss DM. Minutti CM, et al. Among authors: griggs dw. Immunity. 2019 Mar 19;50(3):645-654.e6. doi: 10.1016/j.immuni.2019.01.008. Epub 2019 Feb 12. Immunity. 2019. PMID: 30770250 Free PMC article.
Adenovirus inhibition by peptidomimetic integrin antagonists.
Hippenmeyer PJ, Ruminski PG, Rico JG, Lu HS, Griggs DW. Hippenmeyer PJ, et al. Among authors: griggs dw. Antiviral Res. 2002 Jul;55(1):169-78. doi: 10.1016/s0166-3542(02)00021-9. Antiviral Res. 2002. PMID: 12076761
Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice.
Ulmasov B, Neuschwander-Tetri BA, Lai J, Monastyrskiy V, Bhat T, Yates MP, Oliva J, Prinsen MJ, Ruminski PG, Griggs DW. Ulmasov B, et al. Among authors: griggs dw. Cell Mol Gastroenterol Hepatol. 2016 Mar 16;2(4):499-518. doi: 10.1016/j.jcmgh.2016.03.004. eCollection 2016 Jul. Cell Mol Gastroenterol Hepatol. 2016. PMID: 28174730 Free PMC article.
Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells.
Karpova D, Rettig MP, Ritchey J, Cancilla D, Christ S, Gehrs L, Chendamarai E, Evbuomwan MO, Holt M, Zhang J, Abou-Ezzi G, Celik H, Wiercinska E, Yang W, Gao F, Eissenberg LG, Heier RF, Arnett SD, Meyers MJ, Prinsen MJ, Griggs DW, Trumpp A, Ruminski PG, Morrow DM, Bonig HB, Link DC, DiPersio JF. Karpova D, et al. Among authors: griggs dw. J Clin Invest. 2019 May 14;129(7):2745-2759. doi: 10.1172/JCI124738. J Clin Invest. 2019. PMID: 31085833 Free PMC article.
Anti-metastatic properties of RGD-peptidomimetic agents S137 and S247.
Shannon KE, Keene JL, Settle SL, Duffin TD, Nickols MA, Westlin M, Schroeter S, Ruminski PG, Griggs DW. Shannon KE, et al. Among authors: griggs dw. Clin Exp Metastasis. 2004;21(2):129-38. doi: 10.1023/b:clin.0000024764.93092.5f. Clin Exp Metastasis. 2004. PMID: 15168730
44 results