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Intestinal DMBT1 expression is modulated by Crohn's disease-associated IL23R variants and by a DMBT1 variant which influences binding of the transcription factors CREB1 and ATF-2.
Diegelmann J, Czamara D, Le Bras E, Zimmermann E, Olszak T, Bedynek A, Göke B, Franke A, Glas J, Brand S. Diegelmann J, et al. Among authors: goke b. PLoS One. 2013 Nov 5;8(11):e77773. doi: 10.1371/journal.pone.0077773. eCollection 2013. PLoS One. 2013. PMID: 24223725 Free PMC article.
rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.
Glas J, Seiderer J, Wetzke M, Konrad A, Török HP, Schmechel S, Tonenchi L, Grassl C, Dambacher J, Pfennig S, Maier K, Griga T, Klein W, Epplen JT, Schiemann U, Folwaczny C, Lohse P, Göke B, Ochsenkühn T, Müller-Myhsok B, Folwaczny M, Mussack T, Brand S. Glas J, et al. Among authors: goke b. PLoS One. 2007 Sep 5;2(9):e819. doi: 10.1371/journal.pone.0000819. PLoS One. 2007. PMID: 17786191 Free PMC article.
Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
Glas J, Seiderer J, Nagy M, Fries C, Beigel F, Weidinger M, Pfennig S, Klein W, Epplen JT, Lohse P, Folwaczny M, Göke B, Ochsenkühn T, Diegelmann J, Müller-Myhsok B, Roeske D, Brand S. Glas J, et al. Among authors: goke b. PLoS One. 2010 Apr 29;5(4):e10373. doi: 10.1371/journal.pone.0010373. PLoS One. 2010. PMID: 20454450 Free PMC article.
The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants.
Glas J, Seiderer J, Tillack C, Pfennig S, Beigel F, Jürgens M, Olszak T, Laubender RP, Weidinger M, Müller-Myhsok B, Göke B, Ochsenkühn T, Lohse P, Diegelmann J, Czamara D, Brand S. Glas J, et al. Among authors: goke b. PLoS One. 2010 Dec 30;5(12):e14466. doi: 10.1371/journal.pone.0014466. PLoS One. 2010. PMID: 21209938 Free PMC article.
CEACAM6 gene variants in inflammatory bowel disease.
Glas J, Seiderer J, Fries C, Tillack C, Pfennig S, Weidinger M, Beigel F, Olszak T, Lass U, Göke B, Ochsenkühn T, Wolf C, Lohse P, Müller-Myhsok B, Diegelmann J, Czamara D, Brand S. Glas J, et al. Among authors: goke b. PLoS One. 2011 Apr 29;6(4):e19319. doi: 10.1371/journal.pone.0019319. PLoS One. 2011. PMID: 21559399 Free PMC article.
A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory proteins.
Diegelmann J, Olszak T, Göke B, Blumberg RS, Brand S. Diegelmann J, et al. Among authors: goke b. J Biol Chem. 2012 Jan 2;287(1):286-298. doi: 10.1074/jbc.M111.294355. Epub 2011 Nov 8. J Biol Chem. 2012. PMID: 22069308 Free PMC article.
PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.
Glas J, Wagner J, Seiderer J, Olszak T, Wetzke M, Beigel F, Tillack C, Stallhofer J, Friedrich M, Steib C, Göke B, Ochsenkühn T, Karbalai N, Diegelmann J, Czamara D, Brand S. Glas J, et al. Among authors: goke b. PLoS One. 2012;7(3):e33682. doi: 10.1371/journal.pone.0033682. Epub 2012 Mar 21. PLoS One. 2012. PMID: 22457781 Free PMC article.
Analysis of IL12B gene variants in inflammatory bowel disease.
Glas J, Seiderer J, Wagner J, Olszak T, Fries C, Tillack C, Friedrich M, Beigel F, Stallhofer J, Steib C, Wetzke M, Göke B, Ochsenkühn T, Diegelmann J, Czamara D, Brand S. Glas J, et al. Among authors: goke b. PLoS One. 2012;7(3):e34349. doi: 10.1371/journal.pone.0034349. Epub 2012 Mar 30. PLoS One. 2012. PMID: 22479607 Free PMC article.
IRGM variants and susceptibility to inflammatory bowel disease in the German population.
Glas J, Seiderer J, Bues S, Stallhofer J, Fries C, Olszak T, Tsekeri E, Wetzke M, Beigel F, Steib C, Friedrich M, Göke B, Diegelmann J, Czamara D, Brand S. Glas J, et al. Among authors: goke b. PLoS One. 2013;8(1):e54338. doi: 10.1371/journal.pone.0054338. Epub 2013 Jan 24. PLoS One. 2013. PMID: 23365659 Free PMC article.
511 results