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Preconditioning of microglia by α-synuclein strongly affects the response induced by toll-like receptor (TLR) stimulation.
Roodveldt C, Labrador-Garrido A, Gonzalez-Rey E, Lachaud CC, Guilliams T, Fernandez-Montesinos R, Benitez-Rondan A, Robledo G, Hmadcha A, Delgado M, Dobson CM, Pozo D. Roodveldt C, et al. Among authors: guilliams t. PLoS One. 2013 Nov 13;8(11):e79160. doi: 10.1371/journal.pone.0079160. eCollection 2013. PLoS One. 2013. PMID: 24236103 Free PMC article.
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.
Chen SW, Drakulic S, Deas E, Ouberai M, Aprile FA, Arranz R, Ness S, Roodveldt C, Guilliams T, De-Genst EJ, Klenerman D, Wood NW, Knowles TP, Alfonso C, Rivas G, Abramov AY, Valpuesta JM, Dobson CM, Cremades N. Chen SW, et al. Among authors: guilliams t. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E1994-2003. doi: 10.1073/pnas.1421204112. Epub 2015 Apr 8. Proc Natl Acad Sci U S A. 2015. PMID: 25855634 Free PMC article.
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, Dobson CM, De Genst E, Klenerman D. Iljina M, et al. Among authors: guilliams t. BMC Biol. 2017 Jul 3;15(1):57. doi: 10.1186/s12915-017-0390-6. BMC Biol. 2017. PMID: 28673288 Free PMC article.
Structure and properties of a complex of α-synuclein and a single-domain camelid antibody.
De Genst EJ, Guilliams T, Wellens J, O'Day EM, Waudby CA, Meehan S, Dumoulin M, Hsu ST, Cremades N, Verschueren KH, Pardon E, Wyns L, Steyaert J, Christodoulou J, Dobson CM. De Genst EJ, et al. Among authors: guilliams t. J Mol Biol. 2010 Sep 17;402(2):326-43. doi: 10.1016/j.jmb.2010.07.001. Epub 2010 Jul 8. J Mol Biol. 2010. PMID: 20620148 Free article.
24 results