Smith T - Search Results

1

Application of Titration-Based Screening for the Rapid Pilot Testing of High-Throughput Assays.

Zhang JH, Kang ZB, Ardayfio O, Ho PI, Smith T, Wallace I, Bowes S, Hill WA, Auld DS. Zhang JH, et al. Among authors: smith t. J Biomol Screen. 2014 Jun;19(5):651-60. doi: 10.1177/1087057113512151. Epub 2013 Nov 18. J Biomol Screen. 2014. PMID: 24246376

2

Comparison of compound administration methods in biochemical assays: effects on apparent compound potency using either assay-ready compound plates or pin tool-delivered compounds.

Smith T, Ho PI, Yue K, Itkin Z, MacDougall D, Paolucci M, Hill A, Auld DS. Smith T, et al. J Biomol Screen. 2013 Jan;18(1):14-25. doi: 10.1177/1087057112455434. Epub 2012 Aug 17. J Biomol Screen. 2013. PMID: 22904199

3

Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign.

Smith TM, Lim SP, Yue K, Busby SA, Arora R, Seh CC, Wright SK, Nutiu R, Niyomrattanakit P, Wan KF, Beer D, Shi PY, Benson TE. Smith TM, et al. J Biomol Screen. 2015 Jan;20(1):153-63. doi: 10.1177/1087057114551141. Epub 2014 Sep 24. J Biomol Screen. 2015. PMID: 25252731

4

A Fluorescence-Based High-Throughput Screening Assay to Identify Growth Inhibitors of the Pathogenic Fungus Aspergillus fumigatus.

Smith TM, Richie DL, Tao J. Smith TM, et al. Methods Mol Biol. 2016;1439:171-9. doi: 10.1007/978-1-4939-3673-1_11. Methods Mol Biol. 2016. PMID: 27316995

5

Matrix-Based Activity Pattern Classification as a Novel Method for the Characterization of Enzyme Inhibitors Derived from High-Throughput Screening.

Auld DS, Jimenez M, Yue K, Busby S, Chen YC, Bowes S, Wendel G, Smith T, Zhang JH. Auld DS, et al. Among authors: smith t. J Biomol Screen. 2016 Dec;21(10):1075-1089. doi: 10.1177/1087057116667255. Epub 2016 Sep 27. J Biomol Screen. 2016. PMID: 27601436

6

Advancements in Assay Technologies and Strategies to Enable Drug Discovery.

Busby SA, Carbonneau S, Concannon J, Dumelin CE, Lee Y, Numao S, Renaud N, Smith TM, Auld DS. Busby SA, et al. ACS Chem Biol. 2020 Oct 16;15(10):2636-2648. doi: 10.1021/acschembio.0c00495. Epub 2020 Sep 18. ACS Chem Biol. 2020. PMID: 32880443 Review.

7

High-Throughput Screen for Inhibitors of Klebsiella pneumoniae Virulence Using a Tetrahymena pyriformis Co-Culture Surrogate Host Model.

Woods AL, Parker D, Glick MM, Peng Y, Lenoir F, Mulligan E, Yu V, Piizzi G, Lister T, Lilly MD, Dzink-Fox J, Jansen JM, Ryder NS, Dean CR, Smith TM. Woods AL, et al. Among authors: smith tm. ACS Omega. 2022 Feb 1;7(6):5401-5414. doi: 10.1021/acsomega.1c06633. eCollection 2022 Feb 15. ACS Omega. 2022. PMID: 35187355 Free PMC article.

8

Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies.

Arora R, Liew CW, Soh TS, Otoo DA, Seh CC, Yue K, Nilar S, Wang G, Yokokawa F, Noble CG, Chen YL, Shi PY, Lescar J, Smith TM, Benson TE, Lim SP. Arora R, et al. J Virol. 2020 Nov 23;94(24):e01130-20. doi: 10.1128/JVI.01130-20. Print 2020 Nov 23. J Virol. 2020. PMID: 32907977 Free PMC article.

9

SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.

Palacino J, Swalley SE, Song C, Cheung AK, Shu L, Zhang X, Van Hoosear M, Shin Y, Chin DN, Keller CG, Beibel M, Renaud NA, Smith TM, Salcius M, Shi X, Hild M, Servais R, Jain M, Deng L, Bullock C, McLellan M, Schuierer S, Murphy L, Blommers MJ, Blaustein C, Berenshteyn F, Lacoste A, Thomas JR, Roma G, Michaud GA, Tseng BS, Porter JA, Myer VE, Tallarico JA, Hamann LG, Curtis D, Fishman MC, Dietrich WF, Dales NA, Sivasankaran R. Palacino J, et al. Nat Chem Biol. 2015 Jul;11(7):511-7. doi: 10.1038/nchembio.1837. Epub 2015 Jun 1. Nat Chem Biol. 2015. PMID: 26030728

10

A Phenotypic Screen Identifies Calcium Overload as a Key Mechanism of β-Cell Glucolipotoxicity.

Vogel J, Yin J, Su L, Wang SX, Zessis R, Fowler S, Chiu CH, Wilson AC, Chen A, Zecri F, Turner G, Smith TM, DeChristopher B, Xing H, Rothman DM, Cai X, Berdichevsky A. Vogel J, et al. Diabetes. 2020 May;69(5):1032-1041. doi: 10.2337/db19-0813. Epub 2020 Feb 20. Diabetes. 2020. PMID: 32079579

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