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The self-association coiled-coil domain of PML is sufficient for the oncogenic conversion of the retinoic acid receptor (RAR) alpha.
Occhionorelli M, Santoro F, Pallavicini I, Gruszka A, Moretti S, Bossi D, Viale A, Shing D, Ronzoni S, Muradore I, Soncini M, Pruneri G, Rafaniello P, Viale G, Pelicci PG, Minucci S. Occhionorelli M, et al. Among authors: pallavicini i. Leukemia. 2011 May;25(5):814-20. doi: 10.1038/leu.2011.18. Epub 2011 Feb 18. Leukemia. 2011. PMID: 21331069
A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.
Santoro F, Botrugno OA, Dal Zuffo R, Pallavicini I, Matthews GM, Cluse L, Barozzi I, Senese S, Fornasari L, Moretti S, Altucci L, Pelicci PG, Chiocca S, Johnstone RW, Minucci S. Santoro F, et al. Among authors: pallavicini i. Blood. 2013 Apr 25;121(17):3459-68. doi: 10.1182/blood-2012-10-461988. Epub 2013 Feb 25. Blood. 2013. PMID: 23440245 Free article.
In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.
Bossi D, Cicalese A, Dellino GI, Luzi L, Riva L, D'Alesio C, Diaferia GR, Carugo A, Cavallaro E, Piccioni R, Barberis M, Mazzarol G, Testori A, Punzi S, Pallavicini I, Tosti G, Giacó L, Melloni G, Heffernan TP, Natoli G, Draetta GF, Minucci S, Pelicci P, Lanfrancone L. Bossi D, et al. Among authors: pallavicini i. Cancer Discov. 2016 Jun;6(6):650-63. doi: 10.1158/2159-8290.CD-15-1200. Epub 2016 May 13. Cancer Discov. 2016. PMID: 27179036
c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer.
Nebbioso A, Carafa V, Conte M, Tambaro FP, Abbondanza C, Martens J, Nees M, Benedetti R, Pallavicini I, Minucci S, Garcia-Manero G, Iovino F, Lania G, Ingenito C, Belsito Petrizzi V, Stunnenberg HG, Altucci L. Nebbioso A, et al. Among authors: pallavicini i. Clin Cancer Res. 2017 May 15;23(10):2542-2555. doi: 10.1158/1078-0432.CCR-15-2388. Epub 2016 Jun 29. Clin Cancer Res. 2017. PMID: 27358484
PML nuclear body disruption impairs DNA double-strand break sensing and repair in APL.
di Masi A, Cilli D, Berardinelli F, Talarico A, Pallavicini I, Pennisi R, Leone S, Antoccia A, Noguera NI, Lo-Coco F, Ascenzi P, Minucci S, Nervi C. di Masi A, et al. Among authors: pallavicini i. Cell Death Dis. 2016 Jul 28;7(7):e2308. doi: 10.1038/cddis.2016.115. Cell Death Dis. 2016. PMID: 27468685 Free PMC article.
Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.
Gerboth S, Frittoli E, Palamidessi A, Baltanas FC, Salek M, Rappsilber J, Giuliani C, Troglio F, Rolland Y, Pruneri G, Kreutmair S, Pallavicini I, Zobel M, Cinquanta M, Minucci S, Gomez C, Santos E, Illert AL, Scita G. Gerboth S, et al. Among authors: pallavicini i. Leukemia. 2018 Mar;32(3):820-827. doi: 10.1038/leu.2017.267. Epub 2017 Aug 18. Leukemia. 2018. PMID: 28819285 Free PMC article.
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