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Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data.
Mosley JD, Van Driest SL, Larkin EK, Weeke PE, Witte JS, Wells QS, Karnes JH, Guo Y, Bastarache L, Olson LM, McCarty CA, Pacheco JA, Jarvik GP, Carrell DS, Larson EB, Crosslin DR, Kullo IJ, Tromp G, Kuivaniemi H, Carey DJ, Ritchie MD, Denny JC, Roden DM. Mosley JD, et al. Among authors: witte js. PLoS One. 2013 Dec 12;8(12):e81503. doi: 10.1371/journal.pone.0081503. eCollection 2013. PLoS One. 2013. PMID: 24349080 Free PMC article.
Comprehensive approach to analyzing rare genetic variants.
Hoffmann TJ, Marini NJ, Witte JS. Hoffmann TJ, et al. Among authors: witte js. PLoS One. 2010 Nov 3;5(11):e13584. doi: 10.1371/journal.pone.0013584. PLoS One. 2010. PMID: 21072163 Free PMC article.
Next generation analytic tools for large scale genetic epidemiology studies of complex diseases.
Mechanic LE, Chen HS, Amos CI, Chatterjee N, Cox NJ, Divi RL, Fan R, Harris EL, Jacobs K, Kraft P, Leal SM, McAllister K, Moore JH, Paltoo DN, Province MA, Ramos EM, Ritchie MD, Roeder K, Schaid DJ, Stephens M, Thomas DC, Weinberg CR, Witte JS, Zhang S, Zöllner S, Feuer EJ, Gillanders EM. Mechanic LE, et al. Among authors: witte js. Genet Epidemiol. 2012 Jan;36(1):22-35. doi: 10.1002/gepi.20652. Epub 2011 Dec 6. Genet Epidemiol. 2012. PMID: 22147673 Free PMC article.
Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).
Chhibber A, Mefford J, Stahl EA, Pendergrass SA, Baldwin RM, Owzar K, Li M, Winer EP, Hudis CA, Zembutsu H, Kubo M, Nakamura Y, McLeod HL, Ratain MJ, Shulman LN, Ritchie MD, Plenge RM, Witte JS, Kroetz DL. Chhibber A, et al. Among authors: witte js. Pharmacogenomics J. 2014 Aug;14(4):336-42. doi: 10.1038/tpj.2014.2. Epub 2014 Feb 11. Pharmacogenomics J. 2014. PMID: 24513692 Free PMC article. Clinical Trial.
Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.
Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM. Goswami S, et al. Clin Pharmacol Ther. 2014 Sep;96(3):370-9. doi: 10.1038/clpt.2014.109. Epub 2014 May 22. Clin Pharmacol Ther. 2014. PMID: 24853734 Free PMC article.
309 results