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Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma.
Budde LE, Berger C, Lin Y, Wang J, Lin X, Frayo SE, Brouns SA, Spencer DM, Till BG, Jensen MC, Riddell SR, Press OW. Budde LE, et al. Among authors: spencer dm. PLoS One. 2013 Dec 17;8(12):e82742. doi: 10.1371/journal.pone.0082742. eCollection 2013. PLoS One. 2013. PMID: 24358223 Free PMC article.
Inducible apoptosis as a safety switch for adoptive cell therapy.
Di Stasi A, Tey SK, Dotti G, Fujita Y, Kennedy-Nasser A, Martinez C, Straathof K, Liu E, Durett AG, Grilley B, Liu H, Cruz CR, Savoldo B, Gee AP, Schindler J, Krance RA, Heslop HE, Spencer DM, Rooney CM, Brenner MK. Di Stasi A, et al. Among authors: spencer dm. N Engl J Med. 2011 Nov 3;365(18):1673-83. doi: 10.1056/NEJMoa1106152. N Engl J Med. 2011. PMID: 22047558 Free PMC article. Clinical Trial.
Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40.
Foster AE, Mahendravada A, Shinners NP, Chang WC, Crisostomo J, Lu A, Khalil M, Morschl E, Shaw JL, Saha S, Duong MT, Collinson-Pautz MR, Torres DL, Rodriguez T, Pentcheva-Hoang T, Bayle JH, Slawin KM, Spencer DM. Foster AE, et al. Among authors: spencer dm. Mol Ther. 2017 Sep 6;25(9):2176-2188. doi: 10.1016/j.ymthe.2017.06.014. Epub 2017 Jul 8. Mol Ther. 2017. PMID: 28697888 Free PMC article.
An inducible caspase 9 safety switch for T-cell therapy.
Straathof KC, Pulè MA, Yotnda P, Dotti G, Vanin EF, Brenner MK, Heslop HE, Spencer DM, Rooney CM. Straathof KC, et al. Among authors: spencer dm. Blood. 2005 Jun 1;105(11):4247-54. doi: 10.1182/blood-2004-11-4564. Epub 2005 Feb 22. Blood. 2005. PMID: 15728125 Free PMC article.
Suicide genes as safety switches in T lymphocytes.
Straathof KC, Spencer DM, Sutton RE, Rooney CM. Straathof KC, et al. Among authors: spencer dm. Cytotherapy. 2003;5(3):227-30. doi: 10.1080/14653240310001497. Cytotherapy. 2003. PMID: 12850790 Review.
Constitutively active MyD88/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies.
Collinson-Pautz MR, Chang WC, Lu A, Khalil M, Crisostomo JW, Lin PY, Mahendravada A, Shinners NP, Brandt ME, Zhang M, Duong M, Bayle JH, Slawin KM, Spencer DM, Foster AE. Collinson-Pautz MR, et al. Among authors: spencer dm. Leukemia. 2019 Sep;33(9):2195-2207. doi: 10.1038/s41375-019-0417-9. Epub 2019 Feb 28. Leukemia. 2019. PMID: 30816327 Free PMC article.
Caspase-10 is an initiator caspase in death receptor signaling.
Wang J, Chun HJ, Wong W, Spencer DM, Lenardo MJ. Wang J, et al. Among authors: spencer dm. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13884-8. doi: 10.1073/pnas.241358198. Proc Natl Acad Sci U S A. 2001. PMID: 11717445 Free PMC article.
Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation.
Zhou X, Dotti G, Krance RA, Martinez CA, Naik S, Kamble RT, Durett AG, Dakhova O, Savoldo B, Di Stasi A, Spencer DM, Lin YF, Liu H, Grilley BJ, Gee AP, Rooney CM, Heslop HE, Brenner MK. Zhou X, et al. Among authors: spencer dm. Blood. 2015 Jun 25;125(26):4103-13. doi: 10.1182/blood-2015-02-628354. Epub 2015 May 14. Blood. 2015. PMID: 25977584 Free PMC article. Clinical Trial.
173 results