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Staufen2 regulates neuronal target RNAs.
Heraud-Farlow JE, Sharangdhar T, Li X, Pfeifer P, Tauber S, Orozco D, Hörmann A, Thomas S, Bakosova A, Farlow AR, Edbauer D, Lipshitz HD, Morris QD, Bilban M, Doyle M, Kiebler MA. Heraud-Farlow JE, et al. Among authors: edbauer d. Cell Rep. 2013 Dec 26;5(6):1511-8. doi: 10.1016/j.celrep.2013.11.039. Epub 2013 Dec 19. Cell Rep. 2013. PMID: 24360961 Free article.
Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.
Orozco D, Tahirovic S, Rentzsch K, Schwenk BM, Haass C, Edbauer D. Orozco D, et al. Among authors: edbauer d. EMBO Rep. 2012 Aug;13(8):759-64. doi: 10.1038/embor.2012.90. Epub 2012 Jun 19. EMBO Rep. 2012. PMID: 22710833 Free PMC article.
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes.
Schwenk BM, Lang CM, Hogl S, Tahirovic S, Orozco D, Rentzsch K, Lichtenthaler SF, Hoogenraad CC, Capell A, Haass C, Edbauer D. Schwenk BM, et al. Among authors: edbauer d. EMBO J. 2014 Mar 3;33(5):450-67. doi: 10.1002/embj.201385857. Epub 2013 Dec 19. EMBO J. 2014. PMID: 24357581 Free PMC article.
Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.
Mori K, Nihei Y, Arzberger T, Zhou Q, Mackenzie IR, Hermann A, Hanisch F; German Consortium for Frontotemporal Lobar Degeneration; Bavarian Brain Banking Alliance; Kamp F, Nuscher B, Orozco D, Edbauer D, Haass C. Mori K, et al. Among authors: edbauer d. EMBO Rep. 2016 Sep;17(9):1314-25. doi: 10.15252/embr.201541724. Epub 2016 Jul 26. EMBO Rep. 2016. PMID: 27461252 Free PMC article.
TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.
Schwenk BM, Hartmann H, Serdaroglu A, Schludi MH, Hornburg D, Meissner F, Orozco D, Colombo A, Tahirovic S, Michaelsen M, Schreiber F, Haupt S, Peitz M, Brüstle O, Küpper C, Klopstock T, Otto M, Ludolph AC, Arzberger T, Kuhn PH, Edbauer D. Schwenk BM, et al. Among authors: edbauer d. EMBO J. 2016 Nov 2;35(21):2350-2370. doi: 10.15252/embj.201694221. Epub 2016 Sep 12. EMBO J. 2016. PMID: 27621269 Free PMC article.
Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G4C2)n expression in C9orf72 ALS/FTD.
Czuppa M, Dhingra A, Zhou Q, Schludi C, König L, Scharf E, Farny D, Dalmia A, Täger J, Castillo-Lizardo M, Katona E, Mori K, Aumer T, Schelter F, Müller M, Carell T, Kalliokoski T, Messinger J, Rizzu P, Heutink P, Edbauer D. Czuppa M, et al. Among authors: edbauer d. Cell Rep. 2022 Jun 7;39(10):110913. doi: 10.1016/j.celrep.2022.110913. Cell Rep. 2022. PMID: 35675776 Free article.
Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1.
Hipke K, Pitter B, Hruscha A, van Bebber F, Modic M, Bansal V, Lewandowski SA, Orozco D, Edbauer D, Bonn S, Haass C, Pohl U, Montanez E, Schmid B. Hipke K, et al. Among authors: edbauer d. Front Cell Dev Biol. 2023 Jun 13;11:1169962. doi: 10.3389/fcell.2023.1169962. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37384248 Free PMC article.
97 results