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BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I.
Cancer Med. 2013 Oct;2(5):611-24. doi: 10.1002/cam4.112. Epub 2013 Aug 20.
Cancer Med. 2013.
PMID: 24403227
Free PMC article.
Inhibition of hypoxia-induced gene transcription by substituted pyrazolyl oxadiazoles: initial lead generation and structure-activity relationships.
Härter M, Thierauch KH, Boyer S, Bhargava A, Ellinghaus P, Beck H, Greschat-Schade S, Hess-Stumpp H, Unterschemmann K.
Härter M, et al. Among authors: unterschemmann k.
ChemMedChem. 2014 Jan;9(1):61-6. doi: 10.1002/cmdc.201300357. Epub 2013 Nov 27.
ChemMedChem. 2014.
PMID: 24285584
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18F-FAZA PET imaging response tracks the reoxygenation of tumors in mice upon treatment with the mitochondrial complex I inhibitor BAY 87-2243.
Chang E, Liu H, Unterschemmann K, Ellinghaus P, Liu S, Gekeler V, Cheng Z, Berndorff D, Gambhir SS.
Chang E, et al. Among authors: unterschemmann k.
Clin Cancer Res. 2015 Jan 15;21(2):335-46. doi: 10.1158/1078-0432.CCR-14-0217. Epub 2014 Nov 7.
Clin Cancer Res. 2015.
PMID: 25381339
Free PMC article.
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Anetumab ravtansine: a novel mesothelin-targeting antibody-drug conjugate cures tumors with heterogeneous target expression favored by bystander effect.
Golfier S, Kopitz C, Kahnert A, Heisler I, Schatz CA, Stelte-Ludwig B, Mayer-Bartschmid A, Unterschemmann K, Bruder S, Linden L, Harrenga A, Hauff P, Scholle FD, Müller-Tiemann B, Kreft B, Ziegelbauer K.
Golfier S, et al. Among authors: unterschemmann k.
Mol Cancer Ther. 2014 Jun;13(6):1537-48. doi: 10.1158/1535-7163.MCT-13-0926. Epub 2014 Apr 8.
Mol Cancer Ther. 2014.
PMID: 24714131
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Hypoxia-inducible factor pathway inhibition resolves tumor hypoxia and improves local tumor control after single-dose irradiation.
Helbig L, Koi L, Brüchner K, Gurtner K, Hess-Stumpp H, Unterschemmann K, Pruschy M, Baumann M, Yaromina A, Zips D.
Helbig L, et al. Among authors: unterschemmann k.
Int J Radiat Oncol Biol Phys. 2014 Jan 1;88(1):159-66. doi: 10.1016/j.ijrobp.2013.09.047.
Int J Radiat Oncol Biol Phys. 2014.
PMID: 24331663
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BAY 87-2243, a novel inhibitor of hypoxia-induced gene activation, improves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts.
Helbig L, Koi L, Brüchner K, Gurtner K, Hess-Stumpp H, Unterschemmann K, Baumann M, Zips D, Yaromina A.
Helbig L, et al. Among authors: unterschemmann k.
Radiat Oncol. 2014 Sep 19;9:207. doi: 10.1186/1748-717X-9-207.
Radiat Oncol. 2014.
PMID: 25234922
Free PMC article.
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Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.
Unterschemmann K, Ehrmann A, Herzig I, Andreevski AL, Lustig K, Schmeck C, Eitner F, Grundmann M.
Unterschemmann K, et al.
Am J Physiol Renal Physiol. 2021 Jan 1;320(1):F61-F73. doi: 10.1152/ajprenal.00373.2020. Epub 2020 Nov 16.
Am J Physiol Renal Physiol. 2021.
PMID: 33196323
Free article.
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