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PI3KCA plays a major role in multiple myeloma and its inhibition with BYL719 decreases proliferation, synergizes with other therapies and overcomes stroma-induced resistance.
Azab F, Vali S, Abraham J, Potter N, Muz B, de la Puente P, Fiala M, Paasch J, Sultana Z, Tyagi A, Abbasi T, Vij R, Azab AK. Azab F, et al. Among authors: de la puente p. Br J Haematol. 2014 Apr;165(1):89-101. doi: 10.1111/bjh.12734. Epub 2014 Jan 9. Br J Haematol. 2014. PMID: 24405121 Free article.
Contemporary drug therapies for multiple myeloma.
de la Puente P, Azab AK. de la Puente P, et al. Drugs Today (Barc). 2013 Sep;49(9):563-73. doi: 10.1358/dot.2013.49.9.2020941. Drugs Today (Barc). 2013. PMID: 24086952 Review.
Molecularly targeted therapies in multiple myeloma.
de la Puente P, Muz B, Azab F, Luderer M, Azab AK. de la Puente P, et al. Leuk Res Treatment. 2014;2014:976567. doi: 10.1155/2014/976567. Epub 2014 Apr 16. Leuk Res Treatment. 2014. PMID: 24829804 Free PMC article. Review.
Newly established myeloma-derived stromal cell line MSP-1 supports multiple myeloma proliferation, migration, and adhesion and induces drug resistance more than normal-derived stroma.
de la Puente P, Quan N, Hoo RS, Muz B, Gilson RC, Luderer M, King J, Achilefu S, Salama NN, Vij R, Azab AK. de la Puente P, et al. Haematologica. 2016 Jul;101(7):e307-11. doi: 10.3324/haematol.2016.142190. Epub 2016 Apr 14. Haematologica. 2016. PMID: 27081175 Free PMC article. No abstract available.
45 results