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A better understanding of why murine models of trauma do not recapitulate the human syndrome.
Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Cuenca AG, Ungaro R, Baslanti TO, McKinley BA, Bihorac A, Cuschieri J, Maier RV, Moore FA, Leeuwenburgh C, Baker HV, Moldawer LL, Efron PA. Gentile LF, et al. Crit Care Med. 2014 Jun;42(6):1406-13. doi: 10.1097/CCM.0000000000000222. Crit Care Med. 2014. PMID: 24413577 Free PMC article.
A genomic analysis of Clostridium difficile infections in blunt trauma patients.
Efron PA, Liu H, Lottenberg L, Cuenca AG, Gentile LF, Miggins MV, Bihorac A, Baker HV, Moore FA, Moldawer LL, Ang DN. Efron PA, et al. Among authors: gentile lf. J Trauma Acute Care Surg. 2013 Jan;74(1):334-8. doi: 10.1097/TA.0b013e3182789426. J Trauma Acute Care Surg. 2013. PMID: 23271108 Free PMC article.
Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients.
Cuenca AG, Gentile LF, Lopez MC, Ungaro R, Liu H, Xiao W, Seok J, Mindrinos MN, Ang D, Baslanti TO, Bihorac A, Efron PA, Cuschieri J, Warren HS, Tompkins RG, Maier RV, Baker HV, Moldawer LL; Inflammation and Host Response to Injury Collaborative Research Program. Cuenca AG, et al. Among authors: gentile lf. Crit Care Med. 2013 May;41(5):1175-85. doi: 10.1097/CCM.0b013e318277131c. Crit Care Med. 2013. PMID: 23388514 Free PMC article.
Aged mice are unable to mount an effective myeloid response to sepsis.
Nacionales DC, Gentile LF, Vanzant E, Lopez MC, Cuenca A, Cuenca AG, Ungaro R, Li Y, Baslanti TO, Bihorac A, Moore FA, Baker HV, Leeuwenburgh C, Moldawer LL, Efron PA. Nacionales DC, et al. Among authors: gentile lf. J Immunol. 2014 Jan 15;192(2):612-22. doi: 10.4049/jimmunol.1302109. Epub 2013 Dec 13. J Immunol. 2014. PMID: 24337739 Free PMC article.
Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma.
Vanzant EL, Lopez CM, Ozrazgat-Baslanti T, Ungaro R, Davis R, Cuenca AG, Gentile LF, Nacionales DC, Cuenca AL, Bihorac A, Leeuwenburgh C, Lanz J, Baker HV, McKinley B, Moldawer LL, Moore FA, Efron PA. Vanzant EL, et al. Among authors: gentile lf. J Trauma Acute Care Surg. 2014 Jan;76(1):21-9; discussion 29-30. doi: 10.1097/TA.0b013e3182ab1ab5. J Trauma Acute Care Surg. 2014. PMID: 24368353 Free PMC article.
Protective immunity and defects in the neonatal and elderly immune response to sepsis.
Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Cuenca AG, Ungaro R, Szpila BE, Larson S, Joseph A, Moore FA, Leeuwenburgh C, Baker HV, Moldawer LL, Efron PA. Gentile LF, et al. J Immunol. 2014 Apr 1;192(7):3156-65. doi: 10.4049/jimmunol.1301726. Epub 2014 Mar 3. J Immunol. 2014. PMID: 24591376 Free PMC article.
Host responses to sepsis vary in different low-lethality murine models.
Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Szpila BE, Cuenca AG, Joseph A, Moore FA, Leeuwenburgh C, Baker HV, Moldawer LL, Efron PA. Gentile LF, et al. PLoS One. 2014 May 1;9(5):e94404. doi: 10.1371/journal.pone.0094404. eCollection 2014. PLoS One. 2014. PMID: 24788351 Free PMC article.
Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.
Vanzant EL, Hilton RE, Lopez CM, Zhang J, Ungaro RF, Gentile LF, Szpila BE, Maier RV, Cuschieri J, Bihorac A, Leeuwenburgh C, Moore FA, Baker HV, Moldawer LL, Brakenridge SC, Efron PA; Inflammation and Host Response to Injury Investigators. Vanzant EL, et al. Among authors: gentile lf. Crit Care. 2015 Mar 4;19(1):77. doi: 10.1186/s13054-015-0788-x. Crit Care. 2015. PMID: 25880307 Free PMC article.
Clostridium difficile Infections after Blunt Trauma: A Different Patient Population?
Vanzant EL, Ozrazgat-Baslanti T, Liu H, Malik S, Davis R, Lanz J, Miggins MV, Gentile LF, Cuenca A, Cuenca AG, Lottenberg L, Moore FA, Ang DN, Bihorac A, Efron PA. Vanzant EL, et al. Among authors: gentile lf. Surg Infect (Larchmt). 2015 Aug;16(4):421-7. doi: 10.1089/sur.2013.141. Epub 2015 Jun 2. Surg Infect (Larchmt). 2015. PMID: 26207402 Free PMC article.
33 results