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4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth.
Foley TL, Rai G, Yasgar A, Daniel T, Baker HL, Attene-Ramos M, Kosa NM, Leister W, Burkart MD, Jadhav A, Simeonov A, Maloney DJ. Foley TL, et al. J Med Chem. 2014 Feb 13;57(3):1063-78. doi: 10.1021/jm401752p. Epub 2014 Jan 22. J Med Chem. 2014. PMID: 24450337 Free PMC article.
Targeting iron assimilation to develop new antibacterials.
Foley TL, Simeonov A. Foley TL, et al. Expert Opin Drug Discov. 2012 Sep;7(9):831-47. doi: 10.1517/17460441.2012.708335. Epub 2012 Jul 19. Expert Opin Drug Discov. 2012. PMID: 22812521 Free PMC article. Review.
Covalent small molecule inhibitors of Ca(2+)-bound S100B.
Cavalier MC, Pierce AD, Wilder PT, Alasady MJ, Hartman KG, Neau DB, Foley TL, Jadhav A, Maloney DJ, Simeonov A, Toth EA, Weber DJ. Cavalier MC, et al. Among authors: foley tl. Biochemistry. 2014 Oct 28;53(42):6628-40. doi: 10.1021/bi5005552. Epub 2014 Oct 14. Biochemistry. 2014. PMID: 25268459 Free PMC article.
86 results