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Long-term niacin treatment induces insulin resistance and adrenergic responsiveness in adipocytes by adaptive downregulation of phosphodiesterase 3B.
Heemskerk MM, van den Berg SA, Pronk AC, van Klinken JB, Boon MR, Havekes LM, Rensen PC, van Dijk KW, van Harmelen V. Heemskerk MM, et al. Among authors: van harmelen v, van dijk kw, van klinken jb, van den berg sa. Am J Physiol Endocrinol Metab. 2014 Apr 1;306(7):E808-13. doi: 10.1152/ajpendo.00641.2013. Epub 2014 Jan 28. Am J Physiol Endocrinol Metab. 2014. PMID: 24473440 Free PMC article.
Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile.
Heemskerk MM, Dharuri HK, van den Berg SA, Jónasdóttir HS, Kloos DP, Giera M, van Dijk KW, van Harmelen V. Heemskerk MM, et al. Among authors: van harmelen v, van dijk kw, van den berg sa. J Lipid Res. 2014 Dec;55(12):2532-40. doi: 10.1194/jlr.M051938. Epub 2014 Oct 15. J Lipid Res. 2014. PMID: 25320342 Free PMC article.
IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement.
van Dam AD, van Beek L, Pronk ACM, van den Berg SM, Van den Bossche J, de Winther MPJ, Koning F, van Kooten C, Rensen PCN, Boon MR, Verbeek JS, van Dijk KW, van Harmelen V. van Dam AD, et al. Among authors: van harmelen v, van den bossche j, van kooten c, van dijk kw, van beek l, van den berg sm. Int J Obes (Lond). 2018 Feb;42(2):260-269. doi: 10.1038/ijo.2017.209. Epub 2017 Aug 30. Int J Obes (Lond). 2018. PMID: 28852207
Salsalate activates brown adipose tissue in mice.
van Dam AD, Nahon KJ, Kooijman S, van den Berg SM, Kanhai AA, Kikuchi T, Heemskerk MM, van Harmelen V, Lombès M, van den Hoek AM, de Winther MP, Lutgens E, Guigas B, Rensen PC, Boon MR. van Dam AD, et al. Among authors: van harmelen v, van den hoek am, van den berg sm. Diabetes. 2015 May;64(5):1544-54. doi: 10.2337/db14-1125. Epub 2014 Dec 4. Diabetes. 2015. PMID: 25475439
FcRγ-chain deficiency reduces the development of diet-induced obesity.
van Beek L, Vroegrijk IO, Katiraei S, Heemskerk MM, van Dam AD, Kooijman S, Rensen PC, Koning F, Verbeek JS, Willems van Dijk K, van Harmelen V. van Beek L, et al. Among authors: van harmelen v, van dam ad. Obesity (Silver Spring). 2015 Dec;23(12):2435-44. doi: 10.1002/oby.21309. Epub 2015 Nov 2. Obesity (Silver Spring). 2015. PMID: 26523352 Free article.
Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation.
van den Heuvel JK, Boon MR, van Hengel I, Peschier-van der Put E, van Beek L, van Harmelen V, van Dijk KW, Pereira AM, Hunt H, Belanoff JK, Rensen PC, Meijer OC. van den Heuvel JK, et al. Among authors: van harmelen v, van hengel i, van dijk kw, van beek l. Br J Pharmacol. 2016 Jun;173(11):1793-804. doi: 10.1111/bph.13477. Epub 2016 Apr 24. Br J Pharmacol. 2016. PMID: 26990179 Free PMC article.
Rev1 deficiency induces replication stress to cause metabolic dysfunction differently in males and females.
In Het Panhuis W, Tsaalbi-Shtylik A, Schönke M, van Harmelen V, Pronk ACM, Streefland TCM, Sips HCM, Afkir S, Willems van Dijk K, Rensen PCN, de Wind N, Kooijman S. In Het Panhuis W, et al. Among authors: van harmelen v. Am J Physiol Endocrinol Metab. 2022 Mar 1;322(3):E319-E329. doi: 10.1152/ajpendo.00357.2021. Epub 2022 Feb 14. Am J Physiol Endocrinol Metab. 2022. PMID: 35156394 Free article.
Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects.
Boon MR, Bakker LE, Haks MC, Quinten E, Schaart G, Van Beek L, Wang Y, Van Schinkel L, Van Harmelen V, Meinders AE, Ottenhoff TH, Van Dijk KW, Guigas B, Jazet IM, Rensen PC. Boon MR, et al. Among authors: van harmelen v, van dijk kw, van beek l, van schinkel l. Clin Sci (Lond). 2015 Jan;128(2):143-51. doi: 10.1042/CS20140179. Clin Sci (Lond). 2015. PMID: 25148551
81 results