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Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.
Huang H, Regan KM, Wang F, Wang D, Smith DI, van Deursen JM, Tindall DJ. Huang H, et al. Among authors: van deursen jm. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1649-54. doi: 10.1073/pnas.0406789102. Epub 2005 Jan 24. Proc Natl Acad Sci U S A. 2005. PMID: 15668399 Free PMC article.
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM. Baker DJ, et al. Among authors: van deursen jm. Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3. Nature. 2016. PMID: 26840489 Free PMC article.
Therapy-Induced Senescence Drives Bone Loss.
Yao Z, Murali B, Ren Q, Luo X, Faget DV, Cole T, Ricci B, Thotala D, Monahan J, van Deursen JM, Baker D, Faccio R, Schwarz JK, Stewart SA. Yao Z, et al. Among authors: van deursen jm. Cancer Res. 2020 Mar 1;80(5):1171-1182. doi: 10.1158/0008-5472.CAN-19-2348. Epub 2020 Jan 13. Cancer Res. 2020. PMID: 31932453 Free PMC article.
GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma.
Dong Z, Yeo KS, Lopez G, Zhang C, Dankert Eggum EN, Rokita JL, Ung CY, Levee TM, Her ZP, Howe CJ, Hou X, van Ree JH, Li S, He S, Tao T, Fritchie K, Torres-Mora J, Lehman JS, Meves A, Razidlo GL, Rathi KS, Weroha SJ, Look AT, van Deursen JM, Li H, Westendorf JJ, Maris JM, Zhu S. Dong Z, et al. Among authors: van deursen jm, van ree jh. Cancer Res. 2021 Jun 1;81(11):2995-3007. doi: 10.1158/0008-5472.CAN-20-1890. Epub 2021 Feb 18. Cancer Res. 2021. PMID: 33602789 Free PMC article.
FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer.
Limzerwala JF, Jeganathan KB, Kloeber JA, Davies BA, Zhang C, Sturmlechner I, Zhong J, Fierro Velasco R, Fields AP, Yuan Y, Baker DJ, Zhou D, Li H, Katzmann DJ, van Deursen JM. Limzerwala JF, et al. Among authors: van deursen jm. Nat Cancer. 2020 Oct;1(10):1010-1024. doi: 10.1038/s43018-020-00116-1. Epub 2020 Oct 12. Nat Cancer. 2020. PMID: 34841254 Free PMC article.
238 results