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All-oral combination of ledipasvir, vedroprevir, tegobuvir, and ribavirin in treatment-naïve patients with genotype 1 HCV infection.
Hepatology. 2014 Jul;60(1):56-64. doi: 10.1002/hep.27053. Epub 2014 May 28.
Hepatology. 2014.
PMID: 24501005
Clinical Trial.
The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function.
Hebner CM, Han B, Brendza KM, Nash M, Sulfab M, Tian Y, Hung M, Fung W, Vivian RW, Trenkle J, Taylor J, Bjornson K, Bondy S, Liu X, Link J, Neyts J, Sakowicz R, Zhong W, Tang H, Schmitz U.
Hebner CM, et al.
PLoS One. 2012;7(6):e39163. doi: 10.1371/journal.pone.0039163. Epub 2012 Jun 13.
PLoS One. 2012.
PMID: 22720059
Free PMC article.
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Macrocyclization by nickel-catalyzed, ester-promoted, epoxide-alkyne reductive coupling: total synthesis of (-)-gloeosporone.
Trenkle JD, Jamison TF.
Trenkle JD, et al.
Angew Chem Int Ed Engl. 2009;48(29):5366-8. doi: 10.1002/anie.200902079.
Angew Chem Int Ed Engl. 2009.
PMID: 19536804
Free PMC article.
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