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Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation.
Murugan D, Albert MH, Langemeier J, Bohne J, Puchalka J, Järvinen PM, Hauck F, Klenk AK, Prell C, Schatz S, Diestelhorst J, Sciskala B, Kohistani N, Belohradsky BH, Müller S, Kirchner T, Walter MR, Bufler P, Muise AM, Snapper SB, Koletzko S, Klein C, Kotlarz D. Murugan D, et al. Among authors: kirchner t. J Clin Immunol. 2014 Apr;34(3):331-9. doi: 10.1007/s10875-014-9992-8. Epub 2014 Feb 12. J Clin Immunol. 2014. PMID: 24519095
Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease.
Avitzur Y, Guo C, Mastropaolo LA, Bahrami E, Chen H, Zhao Z, Elkadri A, Dhillon S, Murchie R, Fattouh R, Huynh H, Walker JL, Wales PW, Cutz E, Kakuta Y, Dudley J, Kammermeier J, Powrie F, Shah N, Walz C, Nathrath M, Kotlarz D, Puchaka J, Krieger JR, Racek T, Kirchner T, Walters TD, Brumell JH, Griffiths AM, Rezaei N, Rashtian P, Najafi M, Monajemzadeh M, Pelsue S, McGovern DP, Uhlig HH, Schadt E, Klein C, Snapper SB, Muise AM. Avitzur Y, et al. Among authors: kirchner t. Gastroenterology. 2014 Apr;146(4):1028-39. doi: 10.1053/j.gastro.2014.01.015. Epub 2014 Jan 11. Gastroenterology. 2014. PMID: 24417819 Free PMC article.
Endothelial Dysfunction, and A Prothrombotic, Proinflammatory Phenotype Is Caused by Loss of Mitochondrial Thioredoxin Reductase in Endothelium.
Kirsch J, Schneider H, Pagel JI, Rehberg M, Singer M, Hellfritsch J, Chillo O, Schubert KM, Qiu J, Pogoda K, Kameritsch P, Uhl B, Pircher J, Deindl E, Müller S, Kirchner T, Pohl U, Conrad M, Beck H. Kirsch J, et al. Among authors: kirchner t. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1891-9. doi: 10.1161/ATVBAHA.116.307843. Epub 2016 Jul 7. Arterioscler Thromb Vasc Biol. 2016. PMID: 27386940
TNF-α-induced protein 3 is a key player in childhood asthma development and environment-mediated protection.
Krusche J, Twardziok M, Rehbach K, Böck A, Tsang MS, Schröder PC, Kumbrink J, Kirchner T, Xing Y, Riedler J, Dalphin JC, Pekkanen J, Lauener R, Roponen M, Li J, Wong CK, Wong GWK, Schaub B; PASTURE study group. Krusche J, et al. Among authors: kirchner t. J Allergy Clin Immunol. 2019 Dec;144(6):1684-1696.e12. doi: 10.1016/j.jaci.2019.07.029. Epub 2019 Aug 2. J Allergy Clin Immunol. 2019. PMID: 31381928 Clinical Trial.
Mixed large cell neuroendocrine carcinoma and squamous cell carcinoma of the colon: detailed molecular characterisation of two cases indicates a distinct colorectal cancer entity.
Woischke C, Jung P, Jung A, Kumbrink J, Eisenlohr S, Auernhammer CJ, Vieth M, Kirchner T, Neumann J. Woischke C, et al. Among authors: kirchner t. J Pathol Clin Res. 2021 Jan;7(1):75-85. doi: 10.1002/cjp2.183. Epub 2020 Nov 16. J Pathol Clin Res. 2021. PMID: 33197299 Free PMC article.
The mitochondrial thioredoxin reductase system (TrxR2) in vascular endothelium controls peroxynitrite levels and tissue integrity.
Kameritsch P, Singer M, Nuernbergk C, Rios N, Reyes AM, Schmidt K, Kirsch J, Schneider H, Müller S, Pogoda K, Cui R, Kirchner T, de Wit C, Lange-Sperandio B, Pohl U, Conrad M, Radi R, Beck H. Kameritsch P, et al. Among authors: kirchner t. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e1921828118. doi: 10.1073/pnas.1921828118. Proc Natl Acad Sci U S A. 2021. PMID: 33579817 Free PMC article.
768 results