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Targeting the pancreatic β-cell to treat diabetes.
Vetere A, Choudhary A, Burns SM, Wagner BK. Vetere A, et al. Nat Rev Drug Discov. 2014 Apr;13(4):278-89. doi: 10.1038/nrd4231. Epub 2014 Feb 14. Nat Rev Drug Discov. 2014. PMID: 24525781 Review.
A human islet cell culture system for high-throughput screening.
Walpita D, Hasaka T, Spoonamore J, Vetere A, Takane KK, Fomina-Yadlin D, Fiaschi-Taesch N, Shamji A, Clemons PA, Stewart AF, Schreiber SL, Wagner BK. Walpita D, et al. Among authors: vetere a. J Biomol Screen. 2012 Apr;17(4):509-18. doi: 10.1177/1087057111430253. Epub 2011 Dec 7. J Biomol Screen. 2012. PMID: 22156222 Free PMC article.
Chemical methods to induce Beta-cell proliferation.
Vetere A, Wagner BK. Vetere A, et al. Int J Endocrinol. 2012;2012:925143. doi: 10.1155/2012/925143. Epub 2012 Jun 28. Int J Endocrinol. 2012. PMID: 22811709 Free PMC article.
Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling.
Chou DH, Vetere A, Choudhary A, Scully SS, Schenone M, Tang A, Gomez R, Burns SM, Lundh M, Vital T, Comer E, Faloon PW, Dančík V, Ciarlo C, Paulk J, Dai M, Reddy C, Sun H, Young M, Donato N, Jaffe J, Clemons PA, Palmer M, Carr SA, Schreiber SL, Wagner BK. Chou DH, et al. Among authors: vetere a. J Am Chem Soc. 2015 Jun 24;137(24):7929-34. doi: 10.1021/jacs.5b04284. Epub 2015 Jun 15. J Am Chem Soc. 2015. PMID: 26042473 Free PMC article.
An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.
Wagner FF, Lundh M, Kaya T, McCarren P, Zhang YL, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, Vetere A, Richardson S, Morgan NG, Christensen DP, Gilbert TJ, Hooker JM, Leroy M, Walpita D, Mandrup-Poulsen T, Wagner BK, Holson EB. Wagner FF, et al. Among authors: vetere a. ACS Chem Biol. 2016 Feb 19;11(2):363-74. doi: 10.1021/acschembio.5b00640. Epub 2015 Dec 7. ACS Chem Biol. 2016. PMID: 26640968
Inhibition of DYRK1A Stimulates Human β-Cell Proliferation.
Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dančík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK. Dirice E, et al. Among authors: vetere a. Diabetes. 2016 Jun;65(6):1660-71. doi: 10.2337/db15-1127. Epub 2016 Mar 7. Diabetes. 2016. PMID: 26953159 Free PMC article.
Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells.
Lee M, Maji B, Manna D, Kahraman S, Elgamal RM, Small J, Kokkonda P, Vetere A, Goldberg JM, Lippard SJ, Kulkarni RN, Wagner BK, Choudhary A. Lee M, et al. Among authors: vetere a. J Am Chem Soc. 2020 Apr 8;142(14):6477-6482. doi: 10.1021/jacs.0c00099. Epub 2020 Mar 16. J Am Chem Soc. 2020. PMID: 32175731 Free PMC article.
Emerging diabetes therapies: Bringing back the β-cells.
Basile G, Qadir MMF, Mauvais-Jarvis F, Vetere A, Shoba V, Modell AE, Pastori RL, Russ HA, Wagner BK, Dominguez-Bendala J. Basile G, et al. Among authors: vetere a. Mol Metab. 2022 Jun;60:101477. doi: 10.1016/j.molmet.2022.101477. Epub 2022 Mar 21. Mol Metab. 2022. PMID: 35331962 Free PMC article. Review.
108 results