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OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation.
Singleton RS, Liu-Yi P, Formenti F, Ge W, Sekirnik R, Fischer R, Adam J, Pollard PJ, Wolf A, Thalhammer A, Loenarz C, Flashman E, Yamamoto A, Coleman ML, Kessler BM, Wappner P, Schofield CJ, Ratcliffe PJ, Cockman ME. Singleton RS, et al. Among authors: pollard pj. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4031-6. doi: 10.1073/pnas.1314482111. Epub 2014 Feb 18. Proc Natl Acad Sci U S A. 2014. PMID: 24550447 Free PMC article.
Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α).
Thalhammer A, Bencokova Z, Poole R, Loenarz C, Adam J, O'Flaherty L, Schödel J, Mole D, Giaslakiotis K, Schofield CJ, Hammond EM, Ratcliffe PJ, Pollard PJ. Thalhammer A, et al. Among authors: pollard pj. PLoS One. 2011 Jan 14;6(1):e16210. doi: 10.1371/journal.pone.0016210. PLoS One. 2011. PMID: 21264265 Free PMC article.
Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.
O'Flaherty L, Adam J, Heather LC, Zhdanov AV, Chung YL, Miranda MX, Croft J, Olpin S, Clarke K, Pugh CW, Griffiths J, Papkovsky D, Ashrafian H, Ratcliffe PJ, Pollard PJ. O'Flaherty L, et al. Among authors: pollard pj. Hum Mol Genet. 2010 Oct 1;19(19):3844-51. doi: 10.1093/hmg/ddq305. Epub 2010 Jul 21. Hum Mol Genet. 2010. PMID: 20660115 Free PMC article.
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.
Adam J, Hatipoglu E, O'Flaherty L, Ternette N, Sahgal N, Lockstone H, Baban D, Nye E, Stamp GW, Wolhuter K, Stevens M, Fischer R, Carmeliet P, Maxwell PH, Pugh CW, Frizzell N, Soga T, Kessler BM, El-Bahrawy M, Ratcliffe PJ, Pollard PJ. Adam J, et al. Among authors: pollard pj. Cancer Cell. 2011 Oct 18;20(4):524-37. doi: 10.1016/j.ccr.2011.09.006. Cancer Cell. 2011. PMID: 22014577 Free PMC article.
Cancer. Puzzling patterns of predisposition.
Pollard PJ, Ratcliffe PJ. Pollard PJ, et al. Science. 2009 Apr 10;324(5924):192-4. doi: 10.1126/science.1173362. Science. 2009. PMID: 19359573 No abstract available.
The emerging role of fumarate as an oncometabolite.
Yang M, Soga T, Pollard PJ, Adam J. Yang M, et al. Among authors: pollard pj. Front Oncol. 2012 Jul 31;2:85. doi: 10.3389/fonc.2012.00085. eCollection 2012. Front Oncol. 2012. PMID: 22866264 Free PMC article.
60 results