Fraser G - Search Results

1

Anti-amyloid compounds inhibit α-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA).

Herva ME, Zibaee S, Fraser G, Barker RA, Goedert M, Spillantini MG. Herva ME, et al. Among authors: fraser g. J Biol Chem. 2014 Apr 25;289(17):11897-11905. doi: 10.1074/jbc.M113.542340. Epub 2014 Feb 28. J Biol Chem. 2014. PMID: 24584936 Free PMC article.

2

Sequence Determinants for Amyloid Fibrillogenesis of Human alpha-Synuclein.

Zibaee S, Jakes R, Fraser G, Serpell LC, Crowther RA, Goedert M. Zibaee S, et al. Among authors: fraser g. J Mol Biol. 2007 Nov 23;374(2):454-64. doi: 10.1016/j.jmb.2007.09.039. Epub 2007 Sep 20. J Mol Biol. 2007. PMID: 17936783

3

Human beta-synuclein rendered fibrillogenic by designed mutations.

Zibaee S, Fraser G, Jakes R, Owen D, Serpell LC, Crowther RA, Goedert M. Zibaee S, et al. Among authors: fraser g. J Biol Chem. 2010 Dec 3;285(49):38555-67. doi: 10.1074/jbc.M110.160721. Epub 2010 Sep 10. J Biol Chem. 2010. PMID: 20833719 Free PMC article.

4

Synuclein proteins of the pufferfish Fugu rubripes: sequences and functional characterization.

Yoshida H, Craxton M, Jakes R, Zibaee S, Tavaré R, Fraser G, Serpell LC, Davletov B, Crowther RA, Goedert M. Yoshida H, et al. Among authors: fraser g. Biochemistry. 2006 Feb 28;45(8):2599-607. doi: 10.1021/bi051993m. Biochemistry. 2006. PMID: 16489753

5

Alpha-synuclein adopts an alpha-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation.

Broersen K, van den Brink D, Fraser G, Goedert M, Davletov B. Broersen K, et al. Among authors: fraser g. Biochemistry. 2006 Dec 26;45(51):15610-6. doi: 10.1021/bi061743l. Epub 2006 Dec 7. Biochemistry. 2006. PMID: 17176082

6

In vitro high affinity alpha-synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain.

Ye L, Velasco A, Fraser G, Beach TG, Sue L, Osredkar T, Libri V, Spillantini MG, Goedert M, Lockhart A. Ye L, et al. Among authors: fraser g. J Neurochem. 2008 May;105(4):1428-37. doi: 10.1111/j.1471-4159.2008.05245.x. Epub 2008 Jan 21. J Neurochem. 2008. PMID: 18221373 Free PMC article.

7

Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy.

Delobel P, Lavenir I, Fraser G, Ingram E, Holzer M, Ghetti B, Spillantini MG, Crowther RA, Goedert M. Delobel P, et al. Among authors: fraser g. Am J Pathol. 2008 Jan;172(1):123-31. doi: 10.2353/ajpath.2008.070627. Epub 2007 Dec 13. Am J Pathol. 2008. PMID: 18079436 Free PMC article.

8

Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo.

Schofield DJ, Irving L, Calo L, Bogstedt A, Rees G, Nuccitelli A, Narwal R, Petrone M, Roberts J, Brown L, Cusdin F, Dosanjh B, Lloyd C, Dobson C, Gurrell I, Fraser G, McFarlane M, Rockenstein E, Spencer B, Masliah E, Spillantini MG, Tan K, Billinton A, Vaughan T, Chessell I, Perkinton MS. Schofield DJ, et al. Among authors: fraser g. Neurobiol Dis. 2019 Dec;132:104582. doi: 10.1016/j.nbd.2019.104582. Epub 2019 Aug 21. Neurobiol Dis. 2019. PMID: 31445162 Free article.

9

Assembly of transgenic human P301S Tau is necessary for neurodegeneration in murine spinal cord.

Macdonald JA, Bronner IF, Drynan L, Fan J, Curry A, Fraser G, Lavenir I, Goedert M. Macdonald JA, et al. Among authors: fraser g. Acta Neuropathol Commun. 2019 Mar 18;7(1):44. doi: 10.1186/s40478-019-0695-5. Acta Neuropathol Commun. 2019. PMID: 30885267 Free PMC article.

10

Detection of filamentous tau inclusions by the fluorescent Congo red derivative FSB [(trans,trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene].

Velasco A, Fraser G, Delobel P, Ghetti B, Lavenir I, Goedert M. Velasco A, et al. Among authors: fraser g. FEBS Lett. 2008 Mar 19;582(6):901-6. doi: 10.1016/j.febslet.2008.02.025. Epub 2008 Feb 20. FEBS Lett. 2008. PMID: 18291106 Free PMC article.

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