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A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy.
Chen JA, Wang Q, Davis-Turak J, Li Y, Karydas AM, Hsu SC, Sears RL, Chatzopoulou D, Huang AY, Wojta KJ, Klein E, Lee J, Beekly DL, Boxer A, Faber KM, Haase CM, Miller J, Poon WW, Rosen A, Rosen H, Sapozhnikova A, Shapira J, Varpetian A, Foroud TM, Levenson RW, Levey AI, Kukull WA, Mendez MF, Ringman J, Chui H, Cotman C, DeCarli C, Miller BL, Geschwind DH, Coppola G. Chen JA, et al. Among authors: li y. JAMA Neurol. 2015 Apr;72(4):414-22. doi: 10.1001/jamaneurol.2014.4040. JAMA Neurol. 2015. PMID: 25706306 Free PMC article.
Epigenetic clock analysis of diet, exercise, education, and lifestyle factors.
Quach A, Levine ME, Tanaka T, Lu AT, Chen BH, Ferrucci L, Ritz B, Bandinelli S, Neuhouser ML, Beasley JM, Snetselaar L, Wallace RB, Tsao PS, Absher D, Assimes TL, Stewart JD, Li Y, Hou L, Baccarelli AA, Whitsel EA, Horvath S. Quach A, et al. Among authors: li y. Aging (Albany NY). 2017 Feb 14;9(2):419-446. doi: 10.18632/aging.101168. Aging (Albany NY). 2017. PMID: 28198702 Free PMC article.
DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation.
Richard MA, Huan T, Ligthart S, Gondalia R, Jhun MA, Brody JA, Irvin MR, Marioni R, Shen J, Tsai PC, Montasser ME, Jia Y, Syme C, Salfati EL, Boerwinkle E, Guan W, Mosley TH Jr, Bressler J, Morrison AC, Liu C, Mendelson MM, Uitterlinden AG, van Meurs JB; BIOS Consortium; Franco OH, Zhang G, Li Y, Stewart JD, Bis JC, Psaty BM, Chen YI, Kardia SLR, Zhao W, Turner ST, Absher D, Aslibekyan S, Starr JM, McRae AF, Hou L, Just AC, Schwartz JD, Vokonas PS, Menni C, Spector TD, Shuldiner A, Damcott CM, Rotter JI, Palmas W, Liu Y, Paus T, Horvath S, O'Connell JR, Guo X, Pausova Z, Assimes TL, Sotoodehnia N, Smith JA, Arnett DK, Deary IJ, Baccarelli AA, Bell JT, Whitsel E, Dehghan A, Levy D, Fornage M. Richard MA, et al. Among authors: li y. Am J Hum Genet. 2017 Dec 7;101(6):888-902. doi: 10.1016/j.ajhg.2017.09.028. Epub 2017 Nov 30. Am J Hum Genet. 2017. PMID: 29198723 Free PMC article.
GWAS of epigenetic aging rates in blood reveals a critical role for TERT.
Lu AT, Xue L, Salfati EL, Chen BH, Ferrucci L, Levy D, Joehanes R, Murabito JM, Kiel DP, Tsai PC, Yet I, Bell JT, Mangino M, Tanaka T, McRae AF, Marioni RE, Visscher PM, Wray NR, Deary IJ, Levine ME, Quach A, Assimes T, Tsao PS, Absher D, Stewart JD, Li Y, Reiner AP, Hou L, Baccarelli AA, Whitsel EA, Aviv A, Cardona A, Day FR, Wareham NJ, Perry JRB, Ong KK, Raj K, Lunetta KL, Horvath S. Lu AT, et al. Among authors: li y. Nat Commun. 2018 Jan 26;9(1):387. doi: 10.1038/s41467-017-02697-5. Nat Commun. 2018. PMID: 29374233 Free PMC article.
An epigenetic biomarker of aging for lifespan and healthspan.
Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, Hou L, Baccarelli AA, Stewart JD, Li Y, Whitsel EA, Wilson JG, Reiner AP, Aviv A, Lohman K, Liu Y, Ferrucci L, Horvath S. Levine ME, et al. Among authors: li y. Aging (Albany NY). 2018 Apr 18;10(4):573-591. doi: 10.18632/aging.101414. Aging (Albany NY). 2018. PMID: 29676998 Free PMC article.
Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies.
Horvath S, Oshima J, Martin GM, Lu AT, Quach A, Cohen H, Felton S, Matsuyama M, Lowe D, Kabacik S, Wilson JG, Reiner AP, Maierhofer A, Flunkert J, Aviv A, Hou L, Baccarelli AA, Li Y, Stewart JD, Whitsel EA, Ferrucci L, Matsuyama S, Raj K. Horvath S, et al. Among authors: li y. Aging (Albany NY). 2018 Jul 26;10(7):1758-1775. doi: 10.18632/aging.101508. Aging (Albany NY). 2018. PMID: 30048243 Free PMC article.
DNA methylation GrimAge strongly predicts lifespan and healthspan.
Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj K, Hou L, Baccarelli AA, Li Y, Stewart JD, Whitsel EA, Assimes TL, Ferrucci L, Horvath S. Lu AT, et al. Among authors: li y. Aging (Albany NY). 2019 Jan 21;11(2):303-327. doi: 10.18632/aging.101684. Aging (Albany NY). 2019. PMID: 30669119 Free PMC article.
Optimism is not associated with two indicators of DNA methylation aging.
Kim ES, Fong K, Lee L, Spiro A, Schwartz J, Whitsel E, Horvath S, Wang C, Hou L, Baccarelli AA, Li Y, Stewart J, Manson JE, Grodstein F, DeMeo DL, Kubzansky LD. Kim ES, et al. Among authors: li y. Aging (Albany NY). 2019 Jul 18;11(14):4970-4989. doi: 10.18632/aging.102090. Aging (Albany NY). 2019. PMID: 31322503 Free PMC article.
Non-coding variability at the APOE locus contributes to the Alzheimer's risk.
Zhou X, Chen Y, Mok KY, Kwok TCY, Mok VCT, Guo Q, Ip FC, Chen Y, Mullapudi N; Alzheimer’s Disease Neuroimaging Initiative; Giusti-Rodríguez P, Sullivan PF, Hardy J, Fu AKY, Li Y, Ip NY. Zhou X, et al. Among authors: li y. Nat Commun. 2019 Jul 25;10(1):3310. doi: 10.1038/s41467-019-10945-z. Nat Commun. 2019. PMID: 31346172 Free PMC article.
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