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2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.
Wu SY, Yang X, Gharpure KM, Hatakeyama H, Egli M, McGuire MH, Nagaraja AS, Miyake TM, Rupaimoole R, Pecot CV, Taylor M, Pradeep S, Sierant M, Rodriguez-Aguayo C, Choi HJ, Previs RA, Armaiz-Pena GN, Huang L, Martinez C, Hassell T, Ivan C, Sehgal V, Singhania R, Han HD, Su C, Kim JH, Dalton HJ, Kovvali C, Keyomarsi K, McMillan NA, Overwijk WW, Liu J, Lee JS, Baggerly KA, Lopez-Berestein G, Ram PT, Nawrot B, Sood AK. Wu SY, et al. Among authors: mcmillan na. Nat Commun. 2014 Mar 12;5:3459. doi: 10.1038/ncomms4459. Nat Commun. 2014. PMID: 24619206 Free PMC article.
Lipidic systems for in vivo siRNA delivery.
Wu SY, McMillan NA. Wu SY, et al. Among authors: mcmillan na. AAPS J. 2009 Dec;11(4):639-52. doi: 10.1208/s12248-009-9140-1. Epub 2009 Sep 9. AAPS J. 2009. PMID: 19757082 Free PMC article. Review.
Rational design of immunostimulatory siRNAs.
Gantier MP, Tong S, Behlke MA, Irving AT, Lappas M, Nilsson UW, Latz E, McMillan NA, Williams BR. Gantier MP, et al. Among authors: mcmillan na. Mol Ther. 2010 Apr;18(4):785-95. doi: 10.1038/mt.2010.4. Epub 2010 Feb 2. Mol Ther. 2010. PMID: 20125126 Free PMC article.
RNA interference for the treatment of papillomavirus disease.
Singhania R, Khairuddin N, Clarke D, McMillan NA. Singhania R, et al. Among authors: mcmillan na. Open Virol J. 2012;6:204-15. doi: 10.2174/1874357901206010204. Epub 2012 Dec 28. Open Virol J. 2012. PMID: 23341856 Free PMC article.
132 results