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CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cells.
Jia J, Bosley AD, Thompson A, Hoskins JW, Cheuk A, Collins I, Parikh H, Xiao Z, Ylaya K, Dzyadyk M, Cozen W, Hernandez BY, Lynch CF, Loncarek J, Altekruse SF, Zhang L, Westlake CJ, Factor VM, Thorgeirsson S, Bamlet WR, Hewitt SM, Petersen GM, Andresson T, Amundadottir LT. Jia J, et al. Among authors: westlake cj. Cancer Res. 2014 May 15;74(10):2785-95. doi: 10.1158/0008-5472.CAN-13-3176. Epub 2014 Mar 19. Cancer Res. 2014. PMID: 24648346 Free PMC article.
A 584 bp deletion in CTRB2 inhibits chymotrypsin B2 activity and secretion and confers risk of pancreatic cancer.
Jermusyk A, Zhong J, Connelly KE, Gordon N, Perera S, Abdolalizadeh E, Zhang T, O'Brien A, Hoskins JW, Collins I, Eiser D, Yuan C; PanScan Consortium; PanC4 Consortium; Risch HA, Jacobs EJ, Li D, Du M, Stolzenberg-Solomon RZ, Klein AP, Smith JP, Wolpin BM, Chanock SJ, Shi J, Petersen GM, Westlake CJ, Amundadottir LT. Jermusyk A, et al. Among authors: westlake cj. Am J Hum Genet. 2021 Oct 7;108(10):1852-1865. doi: 10.1016/j.ajhg.2021.09.002. Epub 2021 Sep 23. Am J Hum Genet. 2021. PMID: 34559995 Free PMC article.
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.
Lu Q, Insinna C, Ott C, Stauffer J, Pintado PA, Rahajeng J, Baxa U, Walia V, Cuenca A, Hwang YS, Daar IO, Lopes S, Lippincott-Schwartz J, Jackson PK, Caplan S, Westlake CJ. Lu Q, et al. Among authors: westlake cj. Nat Cell Biol. 2015 Mar;17(3):228-240. doi: 10.1038/ncb3109. Epub 2015 Feb 16. Nat Cell Biol. 2015. PMID: 25686250 Free PMC article.
In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.
Shimada H, Lu Q, Insinna-Kettenhofen C, Nagashima K, English MA, Semler EM, Mahgerefteh J, Cideciyan AV, Li T, Brooks BP, Gunay-Aygun M, Jacobson SG, Cogliati T, Westlake CJ, Swaroop A. Shimada H, et al. Among authors: westlake cj. Cell Rep. 2017 Jul 11;20(2):384-396. doi: 10.1016/j.celrep.2017.06.045. Cell Rep. 2017. PMID: 28700940 Free PMC article.
Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.
Walia V, Cuenca A, Vetter M, Insinna C, Perera S, Lu Q, Ritt DA, Semler E, Specht S, Stauffer J, Morrison DK, Lorentzen E, Westlake CJ. Walia V, et al. Among authors: westlake cj. Dev Cell. 2019 Jul 22;50(2):229-246.e7. doi: 10.1016/j.devcel.2019.05.022. Epub 2019 Jun 13. Dev Cell. 2019. PMID: 31204173 Free PMC article.
46 results