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Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases.
Xie JH, Yamniuk AP, Borowski V, Kuhn R, Susulic V, Rex-Rabe S, Yang X, Zhou X, Zhang Y, Gillooly K, Brosius R, Ravishankar R, Waggie K, Mink K, Price L, Rehfuss R, Tamura J, An Y, Cheng L, Abramczyk B, Ignatovich O, Drew P, Grant S, Bryson JW, Suchard S, Salter-Cid L, Nadler S, Suri A. Xie JH, et al. Among authors: brosius r. J Immunol. 2014 May 1;192(9):4083-92. doi: 10.4049/jimmunol.1303239. Epub 2014 Mar 26. J Immunol. 2014. PMID: 24670803
A monovalent anti-human CD28 domain antibody antagonist: preclinical efficacy and safety.
Suchard SJ, Davis PM, Kansal S, Stetsko DK, Brosius R, Tamura J, Schneeweis L, Bryson J, Salcedo T, Wang H, Yang Z, Fleener CA, Ignatovich O, Plummer C, Grant S, Nadler SG. Suchard SJ, et al. Among authors: brosius r. J Immunol. 2013 Nov 1;191(9):4599-610. doi: 10.4049/jimmunol.1300470. Epub 2013 Sep 30. J Immunol. 2013. PMID: 24081989
Efficacy and tolerability of lasmiditan, an oral 5-HT(1F) receptor agonist, for the acute treatment of migraine: a phase 2 randomised, placebo-controlled, parallel-group, dose-ranging study.
Färkkilä M, Diener HC, Géraud G, Láinez M, Schoenen J, Harner N, Pilgrim A, Reuter U; COL MIG-202 study group. Färkkilä M, et al. Lancet Neurol. 2012 May;11(5):405-13. doi: 10.1016/S1474-4422(12)70047-9. Epub 2012 Mar 28. Lancet Neurol. 2012. PMID: 22459549 Clinical Trial.
Nitroarylhydroxymethylphosphonic acids as inhibitors of CD45.
Beers SA, Malloy EA, Wu W, Wachter MP, Gunnia U, Cavender D, Harris C, Davis J, Brosius R, Pellegrino-Gensey JL, Siekierka J. Beers SA, et al. Among authors: brosius r. Bioorg Med Chem. 1997 Dec;5(12):2203-11. doi: 10.1016/s0968-0896(97)00174-0. Bioorg Med Chem. 1997. PMID: 9459018