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A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice.
Yang Z, Schmidt D, Liu W, Li S, Shi L, Sheng J, Chen K, Yu H, Tremblay JM, Chen X, Piepenbrink KH, Sundberg EJ, Kelly CP, Bai G, Shoemaker CB, Feng H. Yang Z, et al. Among authors: chen k, chen x. J Infect Dis. 2014 Sep 15;210(6):964-72. doi: 10.1093/infdis/jiu196. Epub 2014 Mar 27. J Infect Dis. 2014. PMID: 24683195 Free PMC article.
A mouse model of Clostridium difficile-associated disease.
Chen X, Katchar K, Goldsmith JD, Nanthakumar N, Cheknis A, Gerding DN, Kelly CP. Chen X, et al. Gastroenterology. 2008 Dec;135(6):1984-92. doi: 10.1053/j.gastro.2008.09.002. Epub 2008 Sep 10. Gastroenterology. 2008. PMID: 18848941
Toll-like receptor 5-dependent immunogenicity and protective efficacy of a recombinant fusion protein vaccine containing the nontoxic domains of Clostridium difficile toxins A and B and Salmonella enterica serovar typhimurium flagellin in a mouse model of Clostridium difficile disease.
Ghose C, Verhagen JM, Chen X, Yu J, Huang Y, Chenesseau O, Kelly CP, Ho DD. Ghose C, et al. Among authors: chen x. Infect Immun. 2013 Jun;81(6):2190-6. doi: 10.1128/IAI.01074-12. Epub 2013 Apr 1. Infect Immun. 2013. PMID: 23545305 Free PMC article.
Human monoclonal antibodies against Clostridium difficile toxins A and B inhibit inflammatory and histologic responses to the toxins in human colon and peripheral blood monocytes.
Koon HW, Shih DQ, Hing TC, Yoo JH, Ho S, Chen X, Kelly CP, Targan SR, Pothoulakis C. Koon HW, et al. Among authors: chen x. Antimicrob Agents Chemother. 2013 Jul;57(7):3214-23. doi: 10.1128/AAC.02633-12. Epub 2013 Apr 29. Antimicrob Agents Chemother. 2013. PMID: 23629713 Free PMC article.
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