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A conserved MCM single-stranded DNA binding element is essential for replication initiation.
Elife. 2014 Apr 1;3:e01993. doi: 10.7554/eLife.01993.
Elife. 2014.
PMID: 24692448
Free PMC article.
Analysis of the crystal structure of an active MCM hexamer.
Miller JM, Arachea BT, Epling LB, Enemark EJ.
Miller JM, et al. Among authors: epling lb.
Elife. 2014 Sep 29;3:e03433. doi: 10.7554/eLife.03433.
Elife. 2014.
PMID: 25262915
Free PMC article.
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DNA translocation mechanism of the MCM complex and implications for replication initiation.
Meagher M, Epling LB, Enemark EJ.
Meagher M, et al. Among authors: epling lb.
Nat Commun. 2019 Jul 15;10(1):3117. doi: 10.1038/s41467-019-11074-3.
Nat Commun. 2019.
PMID: 31308367
Free PMC article.
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Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysis.
Epling LB, Grace CR, Lowe BR, Partridge JF, Enemark EJ.
Epling LB, et al.
J Mol Biol. 2015 May 8;427(9):1779-1796. doi: 10.1016/j.jmb.2015.02.015. Epub 2015 Feb 25.
J Mol Biol. 2015.
PMID: 25724843
Free PMC article.
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Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.
Hummel JR, Xiao KJ, Yang JC, Epling LB, Mukai K, Ye Q, Xu M, Qian D, Huo L, Weber M, Roman V, Lo Y, Drake K, Stump K, Covington M, Kapilashrami K, Zhang G, Ye M, Diamond S, Yeleswaram S, Macarron R, Deller MC, Wee S, Kim S, Wang X, Wu L, Yao W.
Hummel JR, et al. Among authors: epling lb.
J Med Chem. 2024 Feb 22;67(4):3112-3126. doi: 10.1021/acs.jmedchem.3c02287. Epub 2024 Feb 7.
J Med Chem. 2024.
PMID: 38325398
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Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3.
Shvartsbart A, Roach JJ, Witten MR, Koblish H, Harris JJ, Covington M, Hess R, Lin L, Frascella M, Truong L, Leffet L, Conlen P, Beshad E, Klabe R, Katiyar K, Kaldon L, Young-Sciame R, He X, Petusky S, Chen KJ, Horsey A, Lei HT, Epling LB, Deller MC, Vechorkin O, Yao W.
Shvartsbart A, et al. Among authors: epling lb.
J Med Chem. 2022 Nov 24;65(22):15433-15442. doi: 10.1021/acs.jmedchem.2c01366. Epub 2022 Nov 10.
J Med Chem. 2022.
PMID: 36356320
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