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Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.
Guigas B, de Leeuw van Weenen JE, van Leeuwen N, Simonis-Bik AM, van Haeften TW, Nijpels G, Houwing-Duistermaat JJ, Beekman M, Deelen J, Havekes LM, Penninx BW, Vogelzangs N, van 't Riet E, Dehghan A, Hofman A, Witteman JC, Uitterlinden AG, Grarup N, Jørgensen T, Witte DR, Lauritzen T, Hansen T, Pedersen O, Hottenga J, Romijn JA, Diamant M, Kramer MH, Heine RJ, Willemsen G, Dekker JM, Eekhoff EM, Pijl H, de Geus EJ, Slagboom PE, 't Hart LM. Guigas B, et al. Among authors: havekes lm. Diabet Med. 2014 Aug;31(8):1001-8. doi: 10.1111/dme.12464. Epub 2014 May 2. Diabet Med. 2014. PMID: 24724616
The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells.
de Leeuw van Weenen JE, Parlevliet ET, Maechler P, Havekes LM, Romijn JA, Ouwens DM, Pijl H, Guigas B. de Leeuw van Weenen JE, et al. Among authors: havekes lm. Biochem Pharmacol. 2010 Jun 15;79(12):1827-36. doi: 10.1016/j.bcp.2010.01.029. Epub 2010 Feb 4. Biochem Pharmacol. 2010. PMID: 20138024
Gut-brain axis.
Romijn JA, Corssmit EP, Havekes LM, Pijl H. Romijn JA, et al. Among authors: havekes lm. Curr Opin Clin Nutr Metab Care. 2008 Jul;11(4):518-21. doi: 10.1097/MCO.0b013e328302c9b0. Curr Opin Clin Nutr Metab Care. 2008. PMID: 18542016 Review.
CNTO736, a novel glucagon-like peptide-1 receptor agonist, ameliorates insulin resistance and inhibits very low-density lipoprotein production in high-fat-fed mice.
Parlevliet ET, Schröder-van der Elst JP, Corssmit EP, Picha K, O'Neil K, Stojanovic-Susulic V, Ort T, Havekes LM, Romijn JA, Pijl H. Parlevliet ET, et al. Among authors: havekes lm. J Pharmacol Exp Ther. 2009 Jan;328(1):240-8. doi: 10.1124/jpet.108.144154. Epub 2008 Oct 10. J Pharmacol Exp Ther. 2009. PMID: 18849357
448 results