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Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways.
Jansson K, Nguyen AN, Magenheimer BS, Reif GA, Aramadhaka LR, Bello-Reuss E, Wallace DP, Calvet JP, Blanco G. Jansson K, et al. Among authors: blanco g. Am J Physiol Renal Physiol. 2012 Oct;303(7):F982-90. doi: 10.1152/ajprenal.00677.2011. Epub 2012 Aug 1. Am J Physiol Renal Physiol. 2012. PMID: 22859406 Free PMC article.
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