Roush WR - Search Results

1

Casein kinase 1δ-dependent Wee1 protein degradation.

Penas C, Ramachandran V, Simanski S, Lee C, Madoux F, Rahaim RJ, Chauhan R, Barnaby O, Schurer S, Hodder P, Steen J, Roush WR, Ayad NG. Penas C, et al. Among authors: roush wr. J Biol Chem. 2014 Jul 4;289(27):18893-903. doi: 10.1074/jbc.M114.547661. Epub 2014 May 9. J Biol Chem. 2014. PMID: 24817118 Free PMC article.

2

Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds.

Roth J, Madoux F, Hodder P, Roush WR. Roth J, et al. Among authors: roush wr. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2628-32. doi: 10.1016/j.bmcl.2008.03.027. Epub 2008 Mar 14. Bioorg Med Chem Lett. 2008. PMID: 18374567 Free PMC article.

3

An ultra-high throughput cell-based screen for wee1 degradation inhibitors.

Madoux F, Simanski S, Chase P, Mishra JK, Roush WR, Ayad NG, Hodder P. Madoux F, et al. Among authors: roush wr. J Biomol Screen. 2010 Sep;15(8):907-17. doi: 10.1177/1087057110375848. Epub 2010 Jul 26. J Biomol Screen. 2010. PMID: 20660794 Free PMC article.

4

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.

Solt LA, Kumar N, Nuhant P, Wang Y, Lauer JL, Liu J, Istrate MA, Kamenecka TM, Roush WR, Vidović D, Schürer SC, Xu J, Wagoner G, Drew PD, Griffin PR, Burris TP. Solt LA, et al. Among authors: roush wr. Nature. 2011 Apr 28;472(7344):491-4. doi: 10.1038/nature10075. Epub 2011 Apr 17. Nature. 2011. PMID: 21499262 Free PMC article.

5

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.

Roth J, Minond D, Darout E, Liu Q, Lauer J, Hodder P, Fields GB, Roush WR. Roth J, et al. Among authors: roush wr. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7180-4. doi: 10.1016/j.bmcl.2011.09.077. Epub 2011 Sep 22. Bioorg Med Chem Lett. 2011. PMID: 22018790 Free PMC article.

6

Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.

Choi JY, Plummer MS, Starr J, Desbonnet CR, Soutter H, Chang J, Miller JR, Dillman K, Miller AA, Roush WR. Choi JY, et al. Among authors: roush wr. J Med Chem. 2012 Jan 26;55(2):852-70. doi: 10.1021/jm201349f. Epub 2012 Jan 13. J Med Chem. 2012. PMID: 22243413 Free PMC article.

7

Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents.

Yang H, Pinello CE, Luo J, Li D, Wang Y, Zhao LY, Jahn SC, Saldanha SA, Chase P, Planck J, Geary KR, Ma H, Law BK, Roush WR, Hodder P, Liao D. Yang H, et al. Among authors: roush wr. Mol Cancer Ther. 2013 May;12(5):610-20. doi: 10.1158/1535-7163.MCT-12-0930. Epub 2013 Apr 26. Mol Cancer Ther. 2013. PMID: 23625935 Free PMC article.

8

Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties.

Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schürer S, Chen W, Nakanishi S, Licht K, Rosenberg LH, Li L, Feng Y, Cameron MD, Duckett DR, Cleveland JL, Roush WR. Bibian M, et al. Among authors: roush wr. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80. doi: 10.1016/j.bmcl.2013.05.075. Epub 2013 May 31. Bioorg Med Chem Lett. 2013. PMID: 23787102 Free PMC article.

9

Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.

Spicer TP, Jiang J, Taylor AB, Choi JY, Hart PJ, Roush WR, Fields GB, Hodder PS, Minond D. Spicer TP, et al. Among authors: roush wr. J Med Chem. 2014 Nov 26;57(22):9598-611. doi: 10.1021/jm501284e. Epub 2014 Nov 11. J Med Chem. 2014. PMID: 25330343 Free PMC article.

10

GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation.

Penas C, Mishra JK, Wood SD, Schürer SC, Roush WR, Ayad NG. Penas C, et al. Among authors: roush wr. Cell Cycle. 2015;14(3):417-24. doi: 10.4161/15384101.2014.974439. Cell Cycle. 2015. PMID: 25616418 Free PMC article.

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