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A zinc linchpin motif in the MUTYH glycosylase interdomain connector is required for efficient repair of DNA damage.
J Am Chem Soc. 2014 Jun 4;136(22):7829-32. doi: 10.1021/ja502942d. Epub 2014 May 23.
J Am Chem Soc. 2014.
PMID: 24841533
Free PMC article.
Catalytic contributions of key residues in the adenine glycosylase MutY revealed by pH-dependent kinetics and cellular repair assays.
Brinkmeyer MK, Pope MA, David SS.
Brinkmeyer MK, et al.
Chem Biol. 2012 Feb 24;19(2):276-86. doi: 10.1016/j.chembiol.2011.11.011.
Chem Biol. 2012.
PMID: 22365610
Free PMC article.
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Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells.
Raetz AG, Xie Y, Kundu S, Brinkmeyer MK, Chang C, David SS.
Raetz AG, et al. Among authors: brinkmeyer mk.
Carcinogenesis. 2012 Nov;33(11):2301-9. doi: 10.1093/carcin/bgs270. Epub 2012 Aug 26.
Carcinogenesis. 2012.
PMID: 22926731
Free PMC article.
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Distinct functional consequences of MUTYH variants associated with colorectal cancer: Damaged DNA affinity, glycosylase activity and interaction with PCNA and Hus1.
Brinkmeyer MK, David SS.
Brinkmeyer MK, et al.
DNA Repair (Amst). 2015 Oct;34:39-51. doi: 10.1016/j.dnarep.2015.08.001. Epub 2015 Aug 12.
DNA Repair (Amst). 2015.
PMID: 26377631
Free PMC article.
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Adenine removal activity and bacterial complementation with the human MutY homologue (MUTYH) and Y165C, G382D, P391L and Q324R variants associated with colorectal cancer.
Kundu S, Brinkmeyer MK, Livingston AL, David SS.
Kundu S, et al. Among authors: brinkmeyer mk.
DNA Repair (Amst). 2009 Dec 3;8(12):1400-10. doi: 10.1016/j.dnarep.2009.09.009.
DNA Repair (Amst). 2009.
PMID: 19836313
Free PMC article.
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Ser 524 is a phosphorylation site in MUTYH and Ser 524 mutations alter 8-oxoguanine (OG): a mismatch recognition.
Kundu S, Brinkmeyer MK, Eigenheer RA, David SS.
Kundu S, et al. Among authors: brinkmeyer mk.
DNA Repair (Amst). 2010 Oct 5;9(10):1026-37. doi: 10.1016/j.dnarep.2010.07.002. Epub 2010 Aug 17.
DNA Repair (Amst). 2010.
PMID: 20724227
Free PMC article.
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DSS1 and ssDNA regulate oligomerization of BRCA2.
Le HP, Ma X, Vaquero J, Brinkmeyer M, Guo F, Heyer WD, Liu J.
Le HP, et al.
Nucleic Acids Res. 2020 Aug 20;48(14):7818-7833. doi: 10.1093/nar/gkaa555.
Nucleic Acids Res. 2020.
PMID: 32609828
Free PMC article.
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