Jadhav A - Search Results

1

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer.

Abdel-Fatah TM, Russell R, Albarakati N, Maloney DJ, Dorjsuren D, Rueda OM, Moseley P, Mohan V, Sun H, Abbotts R, Mukherjee A, Agarwal D, Illuzzi JL, Jadhav A, Simeonov A, Ball G, Chan S, Caldas C, Ellis IO, Wilson DM 3rd, Madhusudan S. Abdel-Fatah TM, et al. Among authors: jadhav a. Mol Oncol. 2014 Oct;8(7):1326-38. doi: 10.1016/j.molonc.2014.04.009. Epub 2014 May 13. Mol Oncol. 2014. PMID: 24880630 Free PMC article.

2

Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy.

Abbotts R, Jewell R, Nsengimana J, Maloney DJ, Simeonov A, Seedhouse C, Elliott F, Laye J, Walker C, Jadhav A, Grabowska A, Ball G, Patel PM, Newton-Bishop J, Wilson DM 3rd, Madhusudan S. Abbotts R, et al. Among authors: jadhav a. Oncotarget. 2014 May 30;5(10):3273-86. doi: 10.18632/oncotarget.1926. Oncotarget. 2014. PMID: 24830350 Free PMC article.

3

Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties.

Poletto M, Malfatti MC, Dorjsuren D, Scognamiglio PL, Marasco D, Vascotto C, Jadhav A, Maloney DJ, Wilson DM 3rd, Simeonov A, Tell G. Poletto M, et al. Among authors: jadhav a. Mol Carcinog. 2016 May;55(5):688-704. doi: 10.1002/mc.22313. Epub 2015 Apr 11. Mol Carcinog. 2016. PMID: 25865359 Free PMC article.

4

Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer.

Flach KD, Periyasamy M, Jadhav A, Dorjsuren D, Siefert JC, Hickey TE, Opdam M, Patel H, Canisius S, Wilson DM 3rd, Donaldson Collier M, Prekovic S, Nieuwland M, Kluin RJC, Zakharov AV, Wesseling J, Wessels LFA, Linn SC, Tilley WD, Simeonov A, Ali S, Zwart W. Flach KD, et al. Among authors: jadhav a. Cancer Res. 2020 May 15;80(10):1914-1926. doi: 10.1158/0008-5472.CAN-19-2207. Epub 2020 Mar 19. Cancer Res. 2020. PMID: 32193286

5

FEN1 Blockade for Platinum Chemo-Sensitization and Synthetic Lethality in Epithelial Ovarian Cancers.

Mesquita KA, Ali R, Doherty R, Toss MS, Miligy I, Alblihy A, Dorjsuren D, Simeonov A, Jadhav A, Wilson DM 3rd, Hickson I, Tatum NJ, Rakha EA, Madhusudan S. Mesquita KA, et al. Among authors: jadhav a. Cancers (Basel). 2021 Apr 14;13(8):1866. doi: 10.3390/cancers13081866. Cancers (Basel). 2021. PMID: 33919707 Free PMC article.

6

Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.

Rai G, Vyjayanti VN, Dorjsuren D, Simeonov A, Jadhav A, Wilson DM 3rd, Maloney DJ. Rai G, et al. Among authors: jadhav a. J Med Chem. 2012 Apr 12;55(7):3101-12. doi: 10.1021/jm201537d. Epub 2012 Mar 28. J Med Chem. 2012. PMID: 22455312 Free PMC article.

7

Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection.

Dorjsuren D, Kim D, Vyjayanti VN, Maloney DJ, Jadhav A, Wilson DM 3rd, Simeonov A. Dorjsuren D, et al. Among authors: jadhav a. PLoS One. 2012;7(10):e47974. doi: 10.1371/journal.pone.0047974. Epub 2012 Oct 23. PLoS One. 2012. PMID: 23110144 Free PMC article.

8

Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening.

Hu X, Legler PM, Southall N, Maloney DJ, Simeonov A, Jadhav A. Hu X, et al. Among authors: jadhav a. J Comput Aided Mol Des. 2014 Jul;28(7):765-78. doi: 10.1007/s10822-014-9758-7. Epub 2014 Jun 24. J Comput Aided Mol Des. 2014. PMID: 24958623 Free PMC article.

9

AlphaScreen-Based Assays: Ultra-High-Throughput Screening for Small-Molecule Inhibitors of Challenging Enzymes and Protein-Protein Interactions.

Yasgar A, Jadhav A, Simeonov A, Coussens NP. Yasgar A, et al. Among authors: jadhav a. Methods Mol Biol. 2016;1439:77-98. doi: 10.1007/978-1-4939-3673-1_5. Methods Mol Biol. 2016. PMID: 27316989 Free PMC article.

10

Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1.

Simeonov A, Kulkarni A, Dorjsuren D, Jadhav A, Shen M, McNeill DR, Austin CP, Wilson DM 3rd. Simeonov A, et al. Among authors: jadhav a. PLoS One. 2009 Jun 1;4(6):e5740. doi: 10.1371/journal.pone.0005740. PLoS One. 2009. PMID: 19484131 Free PMC article.

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