Gardin A - Search Results

1

Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator.

Pan S, Gray NS, Gao W, Mi Y, Fan Y, Wang X, Tuntland T, Che J, Lefebvre S, Chen Y, Chu A, Hinterding K, Gardin A, End P, Heining P, Bruns C, Cooke NG, Nuesslein-Hildesheim B. Pan S, et al. Among authors: gardin a. ACS Med Chem Lett. 2013 Jan 4;4(3):333-7. doi: 10.1021/ml300396r. eCollection 2013 Mar 14. ACS Med Chem Lett. 2013. PMID: 24900670 Free PMC article.

2

The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate.

Gergely P, Nuesslein-Hildesheim B, Guerini D, Brinkmann V, Traebert M, Bruns C, Pan S, Gray NS, Hinterding K, Cooke NG, Groenewegen A, Vitaliti A, Sing T, Luttringer O, Yang J, Gardin A, Wang N, Crumb WJ Jr, Saltzman M, Rosenberg M, Wallström E. Gergely P, et al. Among authors: gardin a. Br J Pharmacol. 2012 Nov;167(5):1035-47. doi: 10.1111/j.1476-5381.2012.02061.x. Br J Pharmacol. 2012. PMID: 22646698 Free PMC article. Clinical Trial.

3

Siponimod (BAF312) penetrates, distributes, and acts in the central nervous system: Preclinical insights.

Bigaud M, Rudolph B, Briard E, Beerli C, Hofmann A, Hermes E, Muellershausen F, Schubart A, Gardin A. Bigaud M, et al. Among authors: gardin a. Mult Scler J Exp Transl Clin. 2021 Nov 3;7(4):20552173211049168. doi: 10.1177/20552173211049168. eCollection 2021 Oct. Mult Scler J Exp Transl Clin. 2021. PMID: 34777855 Free PMC article.

4

Siponimod pharmacokinetics, safety, and tolerability in combination with the potent CYP3A4 inhibitor itraconazole in healthy subjects with different CYP2C9 genotypes.

Gardin A, Shakeri-Nejad K, Feller A, Huth F, Neelakantham S, Dumitras S. Gardin A, et al. Eur J Clin Pharmacol. 2019 Nov;75(11):1565-1574. doi: 10.1007/s00228-019-02729-7. Epub 2019 Aug 7. Eur J Clin Pharmacol. 2019. PMID: 31392364 Clinical Trial.

5

Dose titration of BAF312 attenuates the initial heart rate reducing effect in healthy subjects.

Legangneux E, Gardin A, Johns D. Legangneux E, et al. Among authors: gardin a. Br J Clin Pharmacol. 2013 Mar;75(3):831-41. doi: 10.1111/j.1365-2125.2012.04400.x. Br J Clin Pharmacol. 2013. PMID: 22845008 Free PMC article. Clinical Trial.

6

Impact of siponimod on vaccination response in a randomized, placebo-controlled study.

Ufer M, Shakeri-Nejad K, Gardin A, Su Z, Paule I, Marbury TC, Legangneux E. Ufer M, et al. Among authors: gardin a. Neurol Neuroimmunol Neuroinflamm. 2017 Sep 13;4(6):e398. doi: 10.1212/NXI.0000000000000398. eCollection 2017 Nov. Neurol Neuroimmunol Neuroinflamm. 2017. PMID: 28955715 Free PMC article.

7

In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics.

Jin Y, Borell H, Gardin A, Ufer M, Huth F, Camenisch G. Jin Y, et al. Among authors: gardin a. Eur J Clin Pharmacol. 2018 Apr;74(4):455-464. doi: 10.1007/s00228-017-2404-2. Epub 2017 Dec 22. Eur J Clin Pharmacol. 2018. PMID: 29273968 Free PMC article.

8

Metabolism and Disposition of Siponimod, a Novel Selective S1P₁/S1P₅ Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism.

Glaenzel U, Jin Y, Nufer R, Li W, Schroer K, Adam-Stitah S, Peter van Marle S, Legangneux E, Borell H, James AD, Meissner A, Camenisch G, Gardin A. Glaenzel U, et al. Among authors: gardin a. Drug Metab Dispos. 2018 Jul;46(7):1001-1013. doi: 10.1124/dmd.117.079574. Epub 2018 May 7. Drug Metab Dispos. 2018. PMID: 29735753

9

Effect of Fluconazole Coadministration and CYP2C9 Genetic Polymorphism on Siponimod Pharmacokinetics in Healthy Subjects.

Gardin A, Ufer M, Legangneux E, Rossato G, Jin Y, Su Z, Pal P, Li W, Shakeri-Nejad K. Gardin A, et al. Clin Pharmacokinet. 2019 Mar;58(3):349-361. doi: 10.1007/s40262-018-0700-3. Clin Pharmacokinet. 2019. PMID: 30088221 Free PMC article. Clinical Trial.

10

Abuse and dependence potential of sphingosine-1-phosphate (S1P) receptor modulators used in the treatment of multiple sclerosis: a review of literature and public data.

Schoedel KA, Kolly C, Gardin A, Neelakantham S, Shakeri-Nejad K. Schoedel KA, et al. Among authors: gardin a. Psychopharmacology (Berl). 2022 Jan;239(1):1-13. doi: 10.1007/s00213-021-06011-6. Epub 2021 Nov 13. Psychopharmacology (Berl). 2022. PMID: 34773483 Free PMC article. Review.

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