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Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator.
Pan S, Gray NS, Gao W, Mi Y, Fan Y, Wang X, Tuntland T, Che J, Lefebvre S, Chen Y, Chu A, Hinterding K, Gardin A, End P, Heining P, Bruns C, Cooke NG, Nuesslein-Hildesheim B. Pan S, et al. Among authors: lefebvre s. ACS Med Chem Lett. 2013 Jan 4;4(3):333-7. doi: 10.1021/ml300396r. eCollection 2013 Mar 14. ACS Med Chem Lett. 2013. PMID: 24900670 Free PMC article.
A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model.
Pan S, Mi Y, Pally C, Beerli C, Chen A, Guerini D, Hinterding K, Nuesslein-Hildesheim B, Tuntland T, Lefebvre S, Liu Y, Gao W, Chu A, Brinkmann V, Bruns C, Streiff M, Cannet C, Cooke N, Gray N. Pan S, et al. Among authors: lefebvre s. Chem Biol. 2006 Nov;13(11):1227-34. doi: 10.1016/j.chembiol.2006.09.017. Chem Biol. 2006. PMID: 17114004
Phylogeny of the TRAF/MATH domain.
Zapata JM, Martínez-García V, Lefebvre S. Zapata JM, et al. Among authors: lefebvre s. Adv Exp Med Biol. 2007;597:1-24. doi: 10.1007/978-0-387-70630-6_1. Adv Exp Med Biol. 2007. PMID: 17633013 Review.
Targeting TRAfs for therapeutic intervention.
Zapata JM, Lefebvre S, Reed JC. Zapata JM, et al. Among authors: lefebvre s. Adv Exp Med Biol. 2007;597:188-201. doi: 10.1007/978-0-387-70630-6_15. Adv Exp Med Biol. 2007. PMID: 17633027 Review.
322 results