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Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro.
Paine HA, Nathubhai A, Woon EC, Sunderland PT, Wood PJ, Mahon MF, Lloyd MD, Thompson AS, Haikarainen T, Narwal M, Lehtiö L, Threadgill MD. Paine HA, et al. Among authors: narwal m. Bioorg Med Chem. 2015 Sep 1;23(17):5891-908. doi: 10.1016/j.bmc.2015.06.061. Epub 2015 Jul 2. Bioorg Med Chem. 2015. PMID: 26189030
Homogeneous screening assay for human tankyrase.
Narwal M, Fallarero A, Vuorela P, Lehtiö L. Narwal M, et al. J Biomol Screen. 2012 Jun;17(5):593-604. doi: 10.1177/1087057112436558. Epub 2012 Feb 21. J Biomol Screen. 2012. PMID: 22357873
Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage.
Venkannagari H, Verheugd P, Koivunen J, Haikarainen T, Obaji E, Ashok Y, Narwal M, Pihlajaniemi T, Lüscher B, Lehtiö L. Venkannagari H, et al. Among authors: narwal m. Cell Chem Biol. 2016 Oct 20;23(10):1251-1260. doi: 10.1016/j.chembiol.2016.08.012. Epub 2016 Sep 22. Cell Chem Biol. 2016. PMID: 27667561 Free article.
Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei.
Schlesinger M, Vilchez Larrea SC, Haikarainen T, Narwal M, Venkannagari H, Flawiá MM, Lehtiö L, Fernández Villamil SH. Schlesinger M, et al. Among authors: narwal m. Parasit Vectors. 2016 Mar 23;9:173. doi: 10.1186/s13071-016-1461-1. Parasit Vectors. 2016. PMID: 27007296 Free PMC article.
32 results